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首页> 外文期刊>Journal of Neurophysiology >Effects of short-latency afferent inhibition on short-interval intracortical inhibition
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Effects of short-latency afferent inhibition on short-interval intracortical inhibition

机译：短时延传入抑制对短间隔皮质内抑制的影响

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摘要

Peripheral nerve stimulation inhibits the motor cortex, and the process has been termed short-latency afferent inhibition (SAI) at interstimulus intervals (ISIs) of -20 ms. The objective of the present study was to test how SAI interacts with short-interval intracortical inhibition (SICI) under different stimulation conditions. We studied 20 healthy volunteers. Surface electro-myogram was recorded from the first dorsal interosseous muscle. Using paired- and triple-pulse paradigms, we investigated how SAI interacts with SICI under these different conditions. The effects of different conditioning stimulus (CS) intensities (0.6-0.9 active motor threshold), SAI latencies (23 and 25 ms), and ISIs (2 and 3 ms) for SICI were examined in rest and active conditions. SAI had inhibitory interactions with SICI at different CS intensities for rest or active SICI, at SAI latencies of 23 and 25 ms. This interaction occurred at weak CS intensities for SICI when there was no inhibition, and SICI became facilitatory in the presence of SAI. This can be explained by SICI inhibiting SAI and not by saturation of inhibition. The interaction between SAI and SICI was greater for SICI at ISI of 3 ms than for ISI of 2 ms, suggesting that different circuits may be activated at these ISIs.
机译：周围神经刺激抑制运动皮层，该过程被称为以-20 ms的刺激间隔（ISIs）进行短时延传入抑制（SAI）。本研究的目的是测试在不同刺激条件下SAI如何与短间隔皮层内抑制（SICI）相互作用。我们研究了20名健康志愿者。从第一背骨间肌记录表面肌电图。使用成对脉冲和三脉冲范例，我们研究了在这些不同条件下SAI如何与SICI相互作用。在静止和活跃条件下，检查了不同的条件刺激（CS）强度（0.6-0.9主动运动阈值），SAI潜伏期（23和25 ms）和ISI（2和3 ms）对SICI的影响。 SAI在23和25 ms的SAI潜伏期中，对于静止或活跃的SICI，在不同CS强度下与SICI都有抑制性相互作用。当没有抑制作用时，这种相互作用发生在SICI的CS强度较弱的情况下，并且在SAI存在下，SICI变得容易。这可以通过SICI抑制SAI来解释，而不是通过抑制饱和来解释。在3 ms的ISI上，SICI的SAI和SICI之间的交互作用大于在2 ms的ISI下的交互作用，这表明在这些ISI上可能激活了不同的电路。

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