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首页> 外文期刊>Journal of Neurophysiology >Social context differentially modulates activity of two interneuron populations in an avian basal ganglia nucleus
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Social context differentially modulates activity of two interneuron populations in an avian basal ganglia nucleus

机译：社会背景差异性调节禽基底神经节核中两个中间神经元种群的活动。

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Basal ganglia circuits are critical for the modulation of motor performance across behavioral states. In zebra finches, a cortical-basal ganglia circuit dedicated to singing is necessary for males to adjust their song performance and transition between spontaneous singing, when they are alone (“undirected” song), and a performance state, when they sing to a female (“female-directed” song). However, we know little about the role of different basal ganglia cell types in this behavioral transition or the degree to which behavioral context modulates the activity of different neuron classes. To investigate whether interneurons in the songbird basal ganglia encode information about behavioral state, I recorded from two interneuron types, fast-spiking interneurons (FSI) and external pallidal (GPe) neurons, in the songbird basal ganglia nucleus area X during both female-directed and undirected singing. Both cell types exhibited higher firing rates, more frequent bursting, and greater trial-by-trial variability in firing when male zebra finches produced undirected songs compared with when they produced female-directed songs. However, the magnitude and direction of changes to the firing rate, bursting, and variability of spiking between when birds sat silently and when they sang undirected and female-directed song varied between FSI and GPe neurons. These data indicate that social modulation of activity important for eliciting changes in behavioral state is present in multiple cell types within area X and suggests that social interactions may adjust circuit dynamics during singing at multiple points within the circuit.
机译：基底神经节电路对于跨行为状态调节电机性能至关重要。在斑马雀科中，专用于唱歌的皮质基底神经节回路对于男性来说是必要的，以调节他们的歌唱性能，以及当他们独自一人（“无向”歌声）和向女性唱歌时的表演状态之间的过渡。 （“女性主导”歌曲）。但是，我们对不同的基底节细胞类型在此行为转变中的作用或行为情境调节不同神经元类别的活动的程度了解甚少。为了调查鸣禽基底神经节中的中间神经是否编码有关行为状态的信息，我在两种雌性定向过程中，从鸣鸟基底神经节核区域X中的两种中间神经元类型，即快标中间神经元（FSI）和外苍白（GPe）神经元中进行了记录。和无定向的唱歌。与雄性斑马雀产生非定向歌曲相比，两种细胞类型均具有更高的发芽率，更频繁的爆发和更大的逐次试验变异性。但是，在FSI和GPe神经元之间，鸟鸣无声坐下，唱歌无定向和雌性定向的歌曲之间，射速，爆发和尖峰变化的幅度和方向有所不同。这些数据表明在区域X内的多种细胞类型中存在着对引起行为状态变化重要的活动的社交调节，并表明社交互动可能会在歌唱过程中在电路内的多个点上调节电路动力学。

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