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首页> 外文期刊>Journal of Neurophysiology >Dynamic balance of excitation and inhibition rapidly modulates spike probability and precision in feed-forward hippocampal circuits
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Dynamic balance of excitation and inhibition rapidly modulates spike probability and precision in feed-forward hippocampal circuits

机译：激发和抑制的动态平衡可快速调节前馈海马回路的突波概率和精度

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Feed-forward inhibitory (FFI) circuits are important for many information-processing functions. FFI circuit operations critically depend on the balance and timing between the excitatory and inhibitory components, which undergo rapid dynamic changes during neural activity due to short-term plasticity (STP) of both components. How dynamic changes in excitation/ inhibition (E/I) balance during spike trains influence FFI circuit operations remains poorly understood. In the current study we examined the role of STP in the FFI circuit functions in the mouse hippocampus. Using a coincidence detection paradigm with simultaneous activation of two Schaffer collateral inputs, we found that the spiking probability in the target CA1 neuron was increased while spike precision concomitantly decreased during high-frequency bursts compared with a single spike. Blocking inhibitory synaptic transmission revealed that dynamics of inhibition predominately modulates the spike precision but not the changes in spiking probability, whereas the latter is modulated by the dynamics of excitation. Further analyses combining whole cell recordings and simulations of the FFI circuit suggested that dynamics of the inhibitory circuit component may influence spiking behavior during bursts by broadening the width of excitatory postsynaptic responses and that the strength of this modulation depends on the basal E/I ratio. We verified these predictions using a mouse model of fragile X syndrome, which has an elevated E/I ratio, and found a strongly reduced modulation of postsynaptic response width during bursts. Our results suggest that changes in the dynamics of excitatory and inhibitory circuit components due to STP play important yet distinct roles in modulating the properties of FFI circuits.
机译：前馈抑制（FFI）电路对于许多信息处理功能很重要。 FFI电路的运行关键取决于兴奋性和抑制性成分之间的平衡和时间安排，由于这两个成分的短期可塑性（STP），它们在神经活动过程中会经历快速的动态变化。在尖峰脉冲串期间，激励/抑制（E / I）平衡的动态变化如何影响FFI电路的运行仍知之甚少。在当前的研究中，我们检查了STP在小鼠海马FFI回路功能中的作用。使用同时激活两个Schaffer辅助输入的巧合检测范例，我们发现与单个尖峰相比，在高频突发期间，目标CA1神经元的尖峰概率增加，而尖峰精度随之降低。阻断抑制性突触传递显示抑制的动力学主要调节尖峰的精确度，但不调节尖峰概率的变化，而尖峰概率则由激发的动力学调节。结合全细胞记录和FFI电路模拟进行的进一步分析表明，抑制电路组件的动力学可能会通过加宽兴奋性突触后反应的宽度来影响爆发期间的尖峰行为，并且这种调制的强度取决于基础E / I比。我们使用脆性X综合征的小鼠模型验证了这些预测，该模型具有较高的E / I比，并发现突增期间突触后反应宽度的调节大大降低。我们的结果表明，由STP引起的兴奋性和抑制性电路组件的动力学变化在调制FFI电路的特性中起着重要而又不同的作用。

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