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首页> 外文期刊>Journal of Neurophysiology >Hypergravity within a critical period impacts on the maturation of somatosensory cortical maps and their potential for use-dependent plasticity in the adult
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Hypergravity within a critical period impacts on the maturation of somatosensory cortical maps and their potential for use-dependent plasticity in the adult

机译：关键时期内的超重力会影响体感皮层图的成熟及其在成人中依赖于使用的可塑性的潜力

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摘要

We investigated experience-dependent plasticity of somatosensory maps in rat S1 cortex during early development. We analyzed both short-and long-term effects of exposure to 2G hypergravity (HG) during the first 3 postnatal weeks on forepaw representations. We also examined the potential of adult somatosensory maps for experience-dependent plasticity after early HG rearing. At postnatal day 22, HG was found to induce an enlargement of cortical zones driven by nail displacements and a contraction of skin sectors of the forepaw map. In these remaining zones serving the skin, neurons displayed expanded glabrous skin receptive fields (RFs). HG also induced a bias in the directional sensitivity of neuronal responses to nail displacement. HG-induced map changes were still found after 16 wk of housing in normogravity (NG). However, the glabrous skin RFs recorded in HG rats decreased to values similar to that of NG rats, as early as the end of the first week of housing in NG. Moreover, the expansion of the glabrous skin area and decrease in RF size normally induced in adults by an enriched environment (EE) did not occur in the HG rats, even after 16 wk of EE housing in NG. Our findings reveal that early postnatal experience critically and durably shapes S1 forepaw maps and limits their potential to be modified by novel experience in adulthood.
机译：我们调查了大鼠S1皮质在早期发育过程中体感图的经验依赖性可塑性。我们分析了出生后前三周暴露于2G超重力（HG）的短期和长期影响对前爪的影响。我们还检查了早期HG饲养后成人体感图对于依赖经验的可塑性的潜力。在出生后的第22天，发现HG会导致指甲移位和前爪图的皮肤区域收缩，导致皮质区域扩大。在这些为皮肤服务的其余区域中，神经元显示出扩张的无毛皮肤感受野（RF）。 HG还引起神经元反应对指甲移位的方向敏感性的偏向。在正常重力（NG）的房屋中放置16周后，仍发现HG引起的地图变化。然而，早在NG饲养的第一周结束时，HG大鼠中记录的无毛皮肤RF值就降低到了与NG大鼠相似的值。此外，即使在NG中放置EE 16周后，HG大鼠也没有发生通常由成年人通过富营养化环境（EE）诱导的无毛皮肤区域的扩大和RF大小的减少。我们的发现表明，早期的产后经历严重且持久地塑造了S1前爪图，并限制了其成年后的新经历对其进行修饰的潜力。

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