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首页> 外文期刊>Journal of Neurophysiology >Superentrainment of muscle sympathetic nerve activity during sinusoidal galvanic vestibular stimulation
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Superentrainment of muscle sympathetic nerve activity during sinusoidal galvanic vestibular stimulation

机译：正弦电前庭刺激过程中肌肉交感神经活动的超夹带

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摘要

Sinusoidal galvanic vestibular stimulation (sGVS), delivered at frequencies ranging from 0.08 to 2.0 Hz, induces vestibular illusions of side-to-side motion and robust modulation of muscle sympathetic nerve activity (MSNA) to the lower legs. We have previously documented, in seated subjects, de novo synthesis of bursts of MSNA that are temporally locked to the sinusoidal stimulus rather than to the cardiac-related rhythm. Here we tested the hypothesis that this vestibular entrainment of MSNA is higher in the upright than in the supine position. MSNA was recorded from the common peroneal nerve in 10 subjects lying on a tilt table. Bipolar binaural sGVS (+/- 2 mA, 200 cycles) was applied to the mastoid processes at 0.2, 0.8, and 1.4 Hz in the supine and upright (75 degrees) positions. In four subjects, "superentrainment" of MSNA occurred during sGVS, with strong bursts locked to one phase of the sinusoidal stimulus. This occurred more prominently in the upright position. On average, cross-correlation analysis revealed comparable vestibular modulation of MSNA in both positions at 0.2 Hz (84.9 +/- 3.6% and 78.7 +/- 5.7%), 0.8 Hz (77.4 +/- 3.9% and 74.4 +/- 8.9%), and 1.4 Hz (69.8 +/- 4.6% and 80.2 +/- 7.4%). However, in the supine position there was a significant linear fall in the magnitude of vestibular modulation with increasing frequency, whereas this was not present in the upright position. We conclude that vestibular contributions to the control of blood pressure are higher in the upright position.
机译：频率为0.08至2.0 Hz的正弦电流前庭刺激（sGVS）引起前庭侧向运动的错觉和对小腿肌肉交感神经活动（MSNA）的强烈调节。我们以前已经在坐着的受试者中记录了从头合成MSNA脉冲的合成，这些脉冲在时间上被锁定在正弦刺激而不是与心脏相关的节律上。在这里，我们测试了这样的假设：MSNA的前庭夹带在仰卧位置比仰卧位置高。从倾斜的桌子上的10位受试者的腓总神经中记录了MSNA。将双极双耳sGVS（+/- 2 mA，200个周期）以0.2、0.8和1.4 Hz的仰卧位和直立位（75度）应用于乳突。在四个受试者中，sNAV期间发生了MSNA的“超夹带”，强烈的脉冲锁定在正弦刺激的一个阶段。这种情况在直立位置更为明显。平均而言，互相关分析显示，在0.2 Hz（84.9 +/- 3.6％和78.7 +/- 5.7％），0.8 Hz（77.4 +/- 3.9％和74.4 +/- 8.9）的两个位置上，MSNA的前庭调制均相当％）和1.4 Hz（69.8 +/- 4.6％和80.2 +/- 7.4％）。然而，在仰卧位置，前庭调制的幅度随着频率的增加而出现明显的线性下降，而在直立位置则不存在。我们得出的结论是，在直立位置，前庭对控制血压的贡献较高。

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