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首页> 外文期刊>Journal of Neurophysiology >Demand on skillfulness modulates interhemispheric inhibition of motor cortices
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Demand on skillfulness modulates interhemispheric inhibition of motor cortices

机译：对技能的需求调节运动皮质的半球间抑制

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The role of primary motor cortex (M1) in the control of hand movements is still unclear. Functional magnetic resonance imaging (fMRI) studies of unimanual performance reported a relationship between level of precision of a motor task and additional ipsilateral M1 (iM1) activation. In the present study, we determined whether the demand on accuracy of a movement influences the magnitude of the inhibitory effect between primary motor cortices (IHI). We used transcranial magnetic stimulation (TMS) to measure active IHI (aIHI) of the iM1 on the contralateral M1 (cM1) in the premovement period of a left-hand motor task. Ten healthy participants manipulated a joystick to point to targets of two different sizes. For aIHI, the conditioning stimulus (CS) was applied to iM1, and the test stimulus (TS) to cM1, with an interstimulus interval of 10 ms. The amount of the inhibitory effect of the CS on the motor-evoked potential (MEP) of the subsequent TS was expressed as percentage of the mean MEP amplitude evoked by the single TS. Across different time points of aIHI measurements in the premovement period, there was a significant effect for target size on aIHI. Preparing to point to small targets was associated with weaker aIHI compared with pointing to large targets. The present findings suggest that, during the premovement period, aIHI from iM1 on cM1 is modulated by the demand on accuracy of the motor task. This is consistent with task fMRI findings showing bilateral M1 activation during high-precision movements but only unilateral M1 activity during low-precision movements.
机译：初级运动皮层（M1）在控制手部运动中的作用仍不清楚。功能性磁共振成像（fMRI）对单人性能的研究报告了一项运动任务的精确度与其他同侧M1（iM1）激活之间的关系。在本研究中，我们确定了对运动准确性的要求是否会影响初级运动皮层（IHI）之间抑制作用的大小。我们使用经颅磁刺激（TMS）在左侧运动任务的运动前期测量对侧M1（cM1）上iM1的活动IHI（aIHI）。十名健康的参与者操纵操纵杆指向两个大小不同的目标。对于aIHI，将条件刺激（CS）应用于iM1，将测试刺激（TS）应用于cM1，间隔间隔为10 ms。 CS对后续TS的电机诱发电位（MEP）的抑制作用量表示为单个TS诱发的平均MEP振幅的百分比。在预产期中，在aIHI测量的不同时间点上，目标尺寸对aIHI的影响很大。与指向大目标相比，准备指向小目标与较弱的aIHI有关。本研究结果表明，在运动前期，来自iM1在cM1上的aIHI受运动任务准确性要求的调节。这与任务功能磁共振成像结果一致，后者显示在高精度运动期间双侧M1激活，而在低精度运动期间仅单侧M1激活。

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