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首页> 外文期刊>Journal of Neurophysiology >Predicting binaural responses from monaural responses in the gerbil medial superior olive
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Predicting binaural responses from monaural responses in the gerbil medial superior olive

机译：从沙鼠内侧上橄榄的单耳反应预测双耳反应

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Accurate sound source localization of low-frequency sounds in the horizontal plane depends critically on the comparison of arrival times at both ears. A specialized brainstem circuit containing the principal neurons of the medial superior olive (MSO) is dedicated to this comparison. MSO neurons are innervated by segregated inputs from both ears. The coincident arrival of excitatory inputs from both ears is thought to trigger action potentials, with differences in internal delays creating a unique sensitivity to interaural time differences (ITDs) for each cell. How the inputs from both ears are integrated by the MSO neurons is still debated. Using juxtacellular recordings, we tested to what extent MSO neurons from anesthetized Mongolian gerbils function as simple cross-correlators of their bilateral inputs. From the measured subthreshold responses to monaural wideband stimuli we predicted the rate-ITD functions obtained from the same MSO neuron, which have a damped oscillatory shape. The rate of the oscillations and the position of the peaks and troughs were accurately predicted. The amplitude ratio between dominant and secondary peaks of the rate-ITD function, captured in the width of its envelope, was not always exactly reproduced. This minor imperfection pointed to the methodological limitation of using a linear representation of the monaural inputs, which disregards any temporal sharpening occurring in the cochlear nucleus. The successful prediction of the major aspects of rate-ITD curves supports a simple scheme in which the ITD sensitivity of MSO neurons is realized by the coincidence detection of excitatory monaural inputs.
机译：低频声音在水平面中的准确声源定位主要取决于对两只耳朵到达时间的比较。包含内侧上橄榄（MSO）主要神经元的专门脑干回路专门用于此比较。 MSO神经元被两只耳朵分开的输入所支配。两只耳朵的兴奋性输入信号的同时到达被认为会触发动作电位，内部延迟的差异会导致每个单元对听觉时间差（ITD）的独特敏感性。 MSO神经元如何整合两只耳朵的输入仍然存在争议。使用并列记录，我们测试了麻醉的蒙古沙鼠的MSO神经元在多大程度上作为其双边输入的简单互相关函数。根据对单声道宽带刺激的亚阈值响应测量，我们预测了从同一个MSO神经元获得的速率ITD函数，该神经元具有阻尼振荡形状。准确地预测了振荡的速率以及波峰和波谷的位置。在其包络线的宽度中捕获的速率-ITD函数的主峰和次峰之间的振幅比并不总是精确再现。这种轻微的缺陷指出了使用单声道输入的线性表示的方法学局限性，它忽略了在耳蜗核中发生的任何时间锐化。率-ITD曲线的主要方面的成功预测支持一种简单的方案，其中通过兴奋性单声道输入的重合检测来实现MSO神经元的ITD敏感性。

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