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首页> 外文期刊>Journal of Neurophysiology >Spontaneous activity is correlated with coding density in primary auditory cortex
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Spontaneous activity is correlated with coding density in primary auditory cortex

机译：自发活动与初级听觉皮层的编码密度相关

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摘要

Sensory neurons across sensory modalities and specific processing areas have diverse levels of spontaneous firing rates (SFRs) in the absence of sensory stimuli. However, the functional significance of this spontaneous activity is not well-understood. Previous studies in the auditory system have demonstrated that different levels of spontaneous activity are correlated with a variety of physiological and anatomic properties, suggesting that neurons with differing SFRs make unique contributions to the encoding of auditory stimuli. Additionally, altered SFRs are a correlate of tinnitus, arising in several auditory areas after exposure to ototoxic substances and noise trauma. In this study, we recorded single-unit activity from primary auditory cortex of awake marmoset monkeys while delivering wide-band random-spectrum stimuli and white Gaussian noise (WGN) to examine any divergences in stimulus encoding properties across SFR classes. We found that higher levels of spontaneous activity were associated with both higher levels of activation relative to suppression across a variety of wide-band stimuli and higher driven rates in response to WGN. Moreover, response latencies to WGN were negatively correlated with the level of activation in response to both stimulus types. These findings are consistent with a novel view of the role spontaneous spiking may play during normal stimulus processing in primary auditory cortex and how it may malfunction in cases of tinnitus.
机译：在没有感觉刺激的情况下，跨感觉模态和特定加工区域的感觉神经元具有不同水平的自发放电率（SFR）。但是，这种自发活动的功能意义尚不十分清楚。听觉系统的先前研究表明，不同水平的自发活动与多种生理和解剖学特性相关，这表明具有不同SFR的神经元对听觉刺激的编码做出了独特的贡献。此外，SFR的变化与耳鸣有关，耳鸣是在暴露于耳毒性物质和噪声损伤后在多个听觉区域产生的。在这项研究中，我们记录了醒来的mar猴的主要听觉皮层的单单位活动，同时提供了宽带随机频谱刺激和高斯白噪声（WGN），以检查SFR类中刺激编码特性的任何差异。我们发现，相对于对各种宽带刺激的抑制，较高水平的自发活动与较高水平的激活相关，并且对WGN的响应较高。此外，对WGN的响应潜伏期与对两种刺激类型的响应的激活水平呈负相关。这些发现与新颖的观点一致，即自发尖峰在初级听觉皮层的正常刺激过程中可能起的作用，以及在耳鸣的情况下可能如何发生故障。

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