...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neurophysiology >Slow gamma rhythms in CA3 are entrained by slow gamma activity in the dentate gyrus
【24h】

Slow gamma rhythms in CA3 are entrained by slow gamma activity in the dentate gyrus

机译：齿状回中的慢伽马活动带动了CA3中的慢伽马节律

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In hippocampal area CA1, slow (similar to 25-55 Hz) and fast (similar to 60-100 Hz) gamma rhythms are coupled with different CA1 afferents. CA1 slow gamma is coupled to inputs from CA3, and CA1 fast gamma is coupled to inputs from the medial entorhinal cortex (Colgin LL, Denninger T, Fyhn M, Hafting T, Bonnevie T, Jensen O, Moser MB, Moser EI. Nature 462: 353-357, 2009). CA3 gives rise to highly divergent associational projections, and it is possible that reverberating activity in these connections generates slow gamma rhythms in the hippocampus. However, hippocampal gamma is maximal upstream of CA3, in the dentate gyrus (DG) region (Bragin A, Jando G, Nadasdy Z, Hetke J, Wise K, Buzsaki G. J Neurosci 15: 47-60, 1995). Thus it is possible that slow gamma in CA3 is driven by inputs from DG, yet few studies have examined slow and fast gamma rhythms in DG recordings. Here we investigated slow and fast gamma rhythms in paired recordings from DG and CA3 in freely moving rats to determine whether slow and fast gamma rhythms in CA3 are entrained by DG. We found that slow gamma rhythms, as opposed to fast gamma rhythms, were particularly prominent in DG. We investigated directional causal influences between DG and CA3 by Granger causality analysis and found that DG slow gamma influences CA3 slow gamma. Moreover, DG place cell spikes were strongly phase-locked to CA3 slow gamma rhythms, suggesting that DG excitatory projections to CA3 may underlie this directional influence. These results indicate that slow gamma rhythms do not originate in CA3 but rather slow gamma activity upstream in DG entrains slow gamma rhythms in CA3.
机译：在海马区CA1中，慢速（类似于25-55 Hz）和快速（类似于60-100 Hz）的伽马节律与不同的CA1传入相关。 CA1慢伽玛与来自CA3的输入耦合，而CA1快伽玛与来自内侧内嗅皮层的输入耦合（Colgin LL，Denninger T，Fyhn M，Hafting T，Bonnevie T，Jensen O，Moser MB，Moser EI.Nature 462） ：353-357，2009）。 CA3引起高度不同的联想预测，并且这些连接中的回响活动有可能在海马体中产生缓慢的伽马节律。然而，在齿状回（DG）区域中，海马γ在CA3的上游最大（Bragin A，Jando G，Nadasdy Z，Hetke J，Wise K，Buzsaki G.J Neurosci 15：47-60，1995）。因此，CA3中的慢伽玛可能是由DG的输入驱动的，但是很少有研究检查DG记录中的慢伽玛节奏和快伽玛节奏。在这里，我们研究了自由移动大鼠的DG和CA3配对记录中的慢伽玛节律和快伽玛节律，以确定DG是否带走了CA3慢伽玛节律。我们发现，慢伽玛节奏与快伽玛节奏相反，在DG中尤为突出。我们通过格兰杰因果关系分析研究了DG和CA3之间的定向因果关系，发现DG慢伽玛影响CA3慢伽玛。此外，DG地方细胞峰值强烈锁相到CA3慢伽玛节律，这表明DG对CA3的兴奋性投影可能是这种方向性影响的基础。这些结果表明，慢伽玛节律不是起源于CA3，而是DG上游的慢伽玛活动带动了CA3中的慢伽玛节律。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号