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The need for an effective hangover cure

机译：需要有效的解酒方法

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Background:Emerging data suggest that obesity increases the risk of aggressive prostate cancer (PC), but the mechanisms underlying this relationship remain to be fully elucidated. Oxidative stress (OS) is a key process in the development and progression of PC. Adiponectin, an adipocyte-specific hormone, circulates at relatively high levels in healthy humans, but at reduced levels in obese subjects. Moreover, case-control studies also document lower levels of serum adiponectin in PC patients compared with healthy individuals.Methods:Human 22Rv1 and DU-145 PC cell lines were examined for the generation of OS and detoxification of reactive oxygen species after treatment with adiponectin. Normality was confirmed using the Shapiro-Wilk test and results were analyzed using a one-way analysis of variance.Results:We demonstrate that adiponectin increased cellular anti-oxidative defense mechanisms and inhibited OS in a significant and dose-dependent manner. We show that adiponectin treatment decreased the generation of superoxide anion in both cell lines, whereas the transcript levels of NADPH oxidase (NOX)2 and NOX4 increased. We also found indications of an overall anti-oxidative effect, as the total anti-oxidative potential, catalase activity and protein levels, and manganese superoxide dismutase protein levels increased significantly (P=0.05) in both cell lines after treatment with adiponectin.Conclusion:Lower levels of adiponectin in obese individuals may result in higher levels of prostatic OS, which may explain the clinical association between obesity, hypoadiponectinemia and PC.
机译：背景：新兴数据表明，肥胖症会增加罹患前列腺癌（PC）的风险，但这种关系的潜在机制尚待充分阐明。氧化应激（OS）是PC发育过程中的关键过程。脂联素，一种脂肪细胞特异性激素，在健康人体内以相对较高的水平循环，而在肥胖受试者中则以降低的水平循环。此外，病例对照研究还证明，与健康个体相比，PC患者的血清脂联素水平较低。方法：检查人22Rv1和DU-145 PC细胞系在脂联素治疗后的OS生成和活性氧的解毒作用。通过Shapiro-Wilk检验确认正常，并使用单向方差分析对结果进行分析。结果：我们证明脂联素以显着且剂量依赖性的方式增加了细胞抗氧化防御机制并抑制了OS。我们显示脂联素治疗减少了两个细胞系中超氧阴离子的生成，而NADPH氧化酶（NOX）2和NOX4的转录水平增加。我们还发现了整体抗氧化作用的迹象，因为在用脂联素处理后的两种细胞系中，总抗氧化潜力，过氧化氢酶活性和蛋白质水平以及锰超氧化物歧化酶蛋白质水平显着增加（P = 0.05）。肥胖个体中较低的脂联素水平可能导致较高的前列腺OS水平，这可以解释肥胖症，低脂联素血症和PC之间的临床关联。

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