One from column A and two from column B: the benefits of phage display in molecular-recognition studies

Diane J Rodi; Lee Makowski; Brian K Kay

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One from column A and two from column B: the benefits of phage display in molecular-recognition studies

机译：一个来自A栏，两个来自B栏：噬菌体展示在分子识别研究中的优势

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Recent uses of phage-displayed combinatorial peptide and cDNA libraries have proven invaluable in mapping protein-protein interactions, protein-drug interactions, and the generation of 'molecular therapeutics.' This article reviews some of the findings of the past year and points out some of the pros and cons of phage display as compared with those of yeast two-hybrid screening.

机译：噬菌体展示的组合肽和cDNA文库的最新用途已被证明在绘制蛋白质-蛋白质相互作用，蛋白质-药物相互作用以及“分子疗法”的产生方面具有不可估量的价值。本文回顾了过去一年的一些发现，并指出了与酵母双杂交筛选相比，噬菌体展示的一些利与弊。

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《Current opinion in chemical biology》 |2002年第1期|共5页
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Diane J Rodi; Lee Makowski; Brian K Kay;
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中图分类生物化学;
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1. One from column A and two from column B: the benefits of phage display in molecular-recognition studies [J] . Diane J Rodi, Lee Makowski, Brian K Kay Current opinion in chemical biology . 2002,第1期

机译：一个来自A栏，两个来自B栏：噬菌体展示在分子识别研究中的优势
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3. A 13-bit universal column driver for various displays of OLED and LCD [J] . Seong-Young Ryu, Dong-Hoon Baek, Hyun-Wook Lim, Journal of the Society for Information Display . 2016,第4a6期

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4. Case Study: Designing a 40 Storey High Office Building Using Two Variants, With Regular Concrete Columns and With Compound Ultra-High Performance Concrete Columns and Regular Concrete Columns [C] . Mircea Popa, Zoltan Kiss, Horia Constantinescu International Conference Interdisciplinarity in Engineering . 2016

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5. Analytical and experimental study on slender concrete-filled steel tube columns and beam-columns. [D] . Perea, Tiziano. 2010

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6. Avoiding monocular artifacts in clinical stereotests presented on column-interleaved digital stereoscopic displays [O] . Ignacio Serrano-Pedraza, Kathleen Vancleef, Jenny C. A. Read -1

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7. Figure 4: (A) One conserved sequence, which occurs 79 times in 46,264 binding site peaks from the ChIP-seq data-set. The mutation profile of this conserved sequence is illustrated, where ’_ ’ indicates this base is unchanged; DEL indicates this base is lost; INS X indicates a new base X is inserted in front of this base. (B) Several repeated elements patterns are listed. (C) In the first column, the top five DNA motifs, mined by meme-chip tools (Machanick Bailey, 2011) are illustrated. The resemblant conserved sequences, found by the CFSP algorithm are listed in the second column. In the third column, the position-specific scoring matrices, which are transformed from mutational information are listed. The similarity between meme motif and resemblant conserved sequence with PSSM format was calculated via a stamp motif comparison tool (Mahony Benos, 2007). The E-values for the similarity of those pairs is displayed in the fourth column. (D) One motif is selected in each group clustered by gkmsvm descriptors, and the corresponding motif found by the CFSP algorithm is listed below. (E) There are additional datasets (File No: ENCFF100GRL, ENCFF616IRT, ENCFF870CER, Target: SREBF1) collected from https://www.encodeproject.org. The top two motifs are selected in each file using meme tools, and the corresponding motifs found by our algorithm are listed below. [O] . -1

机译：图4：（a）一种保守序列，其发生在芯片-SEQ数据集中的46,264个结合位点峰值中的79倍。说明了这种保守序列的突变分布，其中'_'表示该碱度不变; del表示此基础丢失; INS X表示新的基础X插入此基础前面。（b）列出了几种重复的元素模式。（c）在第一栏中，示出了由MEME芯片工具（Machanick＆Bailey，2011）开采的前五个DNA主题。由CFSP算法发现的相应保守序列列于第二列中。在第三列中，列出了从突变信息转换的特定位置的评分矩阵。 MEME主题与PSSM格式的相似性与PSSM格式之间的相似性通过邮票图章比较工具（Mahony＆Benos，2007）计算。这些对相似性的电子值显示在第四列中。（d）在由GKMSVM描述符聚集的每个组中选择了一个图案，下面列出了CFSP算法的相应主题。（e）从https://www.encodeproject.org收集的，有附加数据集（文件no：cernff100grl，cenf616irl，conf8.20cer，target：srebf1）。使用MEME工具在每个文件中选择前两个图案，并且我们的算法发现的相应主题如下所示。

One from column A and two from column B: the benefits of phage display in molecular-recognition studies

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