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首页> 外文期刊>Current opinion in endocrinology, diabetes, and obesity >Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states.
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Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states.

机译：轰炸蛋白相关肽及其受体：它们在生理和疾病状态中作用的最新进展。

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PURPOSE OF REVIEW: Mammalian bombesin-related peptides, gastrin-releasing peptide and neuromedin B actions are mediated by two receptors (BB1-receptor, BB2-receptor), which are closely related to the orphan receptor BRS-3 (BB3-receptor). The purpose of this review is to highlight advances in the understanding of these peptides in physiology/disease states. RECENT FINDINGS: Pharmacologic/receptor-knockout studies show involvement of these receptors in a number of new processes/diseases. Neuromedin B/BB1-receptor is an important physiological regulator of pituitary-thyroid function; in mediating behavior, especially feas/anxiety; in mediating satiety through different cascades than gastrin-releasing peptide/BB2 receptors and for its autocrine tumor-growth effects. Gastrin-releasing peptide/BB2-receptor plays important roles in mediating signals for pruritus, lung development/injury, small intestinal mucosal defense, and central nervous system processes such as learning/memory. The signaling mechanisms ofits potent growth effects are being elucidated and their possible therapeutic targets identified. BB3-receptor knockout mice provided insights for their obesity/glucose intolerance and demonstrated that this receptor may be important in the lung response to injury, tumor growth and gastrointestinal motility. Each receptor is frequently overexpressed in human tumors and has potent growth effects. This effect is being explored to develop new antitumor treatments, such as bombesin-receptor ligands conjugated to cytotoxic agents. SUMMARY: This receptor family is involved in an increasing number of central nervous system/peripheral processes physiologically and in disease states, and increased understanding of its role may lead to novel treatments.
机译：审查的目的：哺乳动物轰炸蛋白相关肽，胃泌素释放肽和神经调节素B的作用是由两个受体（BB1-受体，BB2-受体）介导的，这两个受体与孤儿受体BRS-3（BB3-受体）密切相关。这篇综述的目的是强调在生理/疾病状态下对这些肽的理解的进展。最近的发现：药理/受体敲除研究表明这些受体参与了许多新的过程/疾病。 Neuromedin B / BB1-受体是垂体-甲状腺功能的重要生理调节剂。调解行为，尤其是行为/焦虑;通过与胃泌素释放肽/ BB2受体不同的级联介导饱食感及其自分泌肿瘤生长作用。胃泌素释放肽/ BB2受体在介导瘙痒，肺部发育/损伤，小肠粘膜防御以及中枢神经系统过程（例如学习/记忆）的信号中起重要作用。阐明了其有效生长作用的信号传导机制，并确定了其可能的治疗靶标。 BB3受体基因敲除小鼠为他们的肥胖症/葡萄糖不耐症提供了见识，并证明了该受体在肺对损伤，肿瘤生长和胃肠动力的反应中可能很重要。每种受体通常在人肿瘤中过表达，并具有有效的生长作用。人们正在探索这种效果以开发新的抗肿瘤治疗方法，例如与细胞毒性剂偶联的蛙皮素受体配体。概述：该受体家族在生理上和疾病状态下参与越来越多的中枢神经系统/周围过程，并且对其作用的进一步了解可能会导致新的治疗方法。

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