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首页> 外文期刊>Current opinion in endocrinology, diabetes, and obesity >Brown fat as a therapy for obesity and diabetes.
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Brown fat as a therapy for obesity and diabetes.

机译：褐色脂肪可作为肥胖症和糖尿病的疗法。

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摘要

PURPOSE OF REVIEW: Human fat consists of white and brown adipose tissue (WAT and BAT). Though most fat is energy-storing WAT, the thermogenic capacity of even small amounts of BAT makes it an attractive therapeutic target for inducing weight loss through energy expenditure. This review evaluates the recent discoveries regarding the identification of functional BAT in adult humans and its potential as a therapy for obesity and diabetes. RECENT FINDINGS: Over the past year, several independent research teams used a combination of positron-emission tomography and computed tomography (PET/CT) imaging, immunohistochemistry, and gene and protein expression assays to prove conclusively that adult humans have functional BAT. This has occurred against a backdrop of basic studies defining the origins of BAT, new components of its transcriptional regulation, and the role of hormones in stimulation of BAT growth and differentiation. SUMMARY: Adult humans have functional BAT, a new target for antiobesity and antidiabetes therapies focusing on increasing energy expenditure. Future studies will refine the methodologies used to measure BAT mass and activity, expand our knowledge of critical-control points in BAT regulation, and focus on testing pharmacological agents that increase BAT thermogenesis and help achieve long-lasting weight loss and an improved metabolic profile.
机译：审查目的：人体脂肪由白色和棕色脂肪组织（WAT和BAT）组成。尽管大多数脂肪都是储存能量的WAT，但即使是少量BAT的产热能力，也使其成为通过能量消耗引起体重减轻的诱人治疗靶标。这篇综述评估了关于成人功能性BAT鉴定及其作为肥胖症和糖尿病治疗潜力的最新发现。最近的发现：在过去的一年中，几个独立的研究小组结合使用了正电子发射断层扫描和计算机断层扫描（PET / CT）成像，免疫组织化学以及基因和蛋白质表达测定法，以最终证明成年人具有功能性BAT。这是在定义BAT的起源，其转录调控的新成分以及激素在刺激BAT生长和分化中的作用的基础研究的背景下发生的。摘要：成年人具有功能性BAT，这是针对肥胖症和抗糖尿病疗法的新目标，重点是增加能量消耗。未来的研究将完善用于测量BAT量和活性的方法，扩大我们对BAT调节关键控制点的了解，并侧重于测试可提高BAT生热作用并帮助实现长期减肥和改善代谢状况的药理剂。

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