Assessing immune function changes in exercise and diet intervention studies.

Gleeson M

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Assessing immune function changes in exercise and diet intervention studies.

机译：在运动和饮食干预研究中评估免疫功能的变化。

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PURPOSE OF REVIEW: To discuss the advantages and limitations of the methods currently available to assess changes in human immune function in response to interventions such as changes in diet or exercise. RECENT FINDINGS: Much recent research has focused on the effect of regular moderate exercise and the role of foods or specific food components in enhancing immune system responsiveness to challenge and thereby improving health and reducing disease risk. The present review summarizes the issues in experimental design that need to be considered in human intervention studies, the immune function variables commonly used as markers in such studies and the biological relevance (e.g. known correlation with clinically relevant endpoints) of the markers. In-vivo markers appear to be the best. Markers of peripheral blood leukocyte function are also of value since they may provide information on the mechanism(s) of change caused by an intervention. SUMMARY: Currently, no single marker of human immune function isavailable to predict the outcome of an exercise or dietary intervention on the resistance to infection or to other immune system-related diseases. There is too little evidence at present that correlates individual markers with global health improvement and therefore assessing changes of immune function requires a thorough methodological approach targeting a large spectrum of parameters.

机译：审查目的：讨论目前可用于评估人类免疫功能变化的方法的优点和局限性，以应对诸如饮食或运动变化等干预措施。最近的发现：最近的许多研究都集中在定期进行适度运动的效果以及食物或特定食物成分在增强免疫系统对挑战的反应能力，从而改善健康和降低疾病风险中的作用。本综述总结了在人类干预研究中需要考虑的实验设计中的问题，在此类研究中通常用作标记的免疫功能变量以及标记的生物学相关性（例如与临床相关终点的已知相关性）。体内标记似乎是最好的。外周血白细胞功能的标记物也很有价值，因为它们可以提供有关由干预引起的变化机制的信息。概述：目前，尚无人类免疫功能的单一标志物可预测运动或饮食干预对感染或对其他免疫系统相关疾病的抵抗力的结果。目前，几乎没有证据将单个标记物与整体健康状况相关联，因此评估免疫功能的变化需要针对大范围参数的全面方法论方法。

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《Current opinion in clinical nutrition and metabolic care》 |2005年第5期|共5页
作者
Gleeson M;
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正文语种 eng
中图分类临床医学;
关键词
immune function; Exercise; Human; Diet; g lt; 3gt; 运动(Exercise); 膳食;

机译：immune function;Exercise;Human;Diet;g 3;运动(Exercise);膳食;

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1. Assessing immune function changes in exercise and diet intervention studies. [J] . Gleeson M Current opinion in clinical nutrition and metabolic care . 2005,第5期

机译：在运动和饮食干预研究中评估免疫功能的变化。
2. Effects on blood pressure and autonomic nervous system function of a 12-week exercise or exercise plus DASH-diet intervention in individuals with elevated blood pressure [J] . K. M. Edwards, K. L. Wilson, J. Sadja, Acta Physiologica . 2011,第3期

机译：12周运动或运动加DASH饮食干预对高血压患者的血压和自主神经系统功能的影响
3. Methods for assessing body composition, cardiovascular and metabolic function in children and adolescents: implications for exercise studies. [J] . Nassis GP, Sidossis LS Current opinion in clinical nutrition and metabolic care . 2006,第5期

机译：评估儿童和青少年的身体成分，心血管和代谢功能的方法：对运动研究的影响。
4. A Lifestyle Intervention of Exercise and Diet Attenuates Obesogenic Associations of Per- and Polyfluoroalkyl Substances: Results from the Diabetes Prevention Program [C] . Andres Cardenas, Russ Hauser, Diane Gold, Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology . 2018

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5. Developmental Plasticity: The Influence of Neonatal Diet and Immune Challenges on Carotenoid-Based Ornamental Coloration and Adult Immune Function in Mallard Ducks. [D] . Butler, Michael. 2012

机译：发育可塑性：野鸭鸭的新生儿饮食和免疫挑战对基于类胡萝卜素的装饰性着色和成人免疫功能的影响。
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Assessing immune function changes in exercise and diet intervention studies.

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