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首页> 外文期刊>Current Opinion in Neurobiology >Shedding new light on the role of the basal ganglia-superior colliculus pathway in eye movements.
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Shedding new light on the role of the basal ganglia-superior colliculus pathway in eye movements.

机译:揭示了上神经节上丘神经通路在眼球运动中的作用。

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摘要

A large body of work spanning 25+ years provides compelling evidence for the involvement of the basal ganglia-superior colliculus pathway in the initiation of rapid, orienting movements of the eyes, called saccades. The role of this pathway in saccade control is similar to the role of the basal ganglia-thalamic pathway in the control of skeletal movement: a transient cessation in tonic inhibition supplied by the basal ganglia to motor structures releases movements via the direct pathway whereas a transient increase in inhibition by the basal ganglia to motor structures prevents movements via the indirect pathway. In parallel with recent advances in the study and treatment of patients with basal ganglia disease and in animal experiments in the skeletal motor system, the results of studies exploring the role of the basal ganglia-superior colliculus pathway in saccades highlight the need for a revisiting of our understanding of the role of this pathway in saccades. The discovery of many different response profiles of neurons in the substantia nigra pars reticulata of the basal ganglia and in the superior colliculus, coupled with advances in experimental and statistical techniques including sophisticated behavioral procedures and multiple neuron recording and analysis, point toward a role for the basal ganglia-superior colliculus pathway in cognitive events intervening between vision and action, such as memory, target selection and saccade choice and valuation.
机译:跨越25年以上的大量工作为令人信服的证据提供了基础神经节上丘通路参与快速,定向的眼动运动(称为扫视运动)的参与。该途径在扫视控制中的作用类似于基底神经节-丘脑途径在骨骼运动控制中的作用:基底神经节对运动结构的强直性抑制作用的暂时停止通过直接途径释放运动,而短暂的基底神经节对运动结构的抑制作用的增加阻止了通过间接途径的运动。在研究和治疗基底神经节疾病患者的最新进展以及骨骼运动系统中的动物实验的同时,探索基底神经节上丘通路在眼球扫视中的作用的研究结果突出表明,有必要重新研究我们对该路径在扫视中的作用的理解。在基底神经节的黑质网状组织和上丘上层神经元的许多不同反应模式中发现,再加上实验和统计技术的进步,包括复杂的行为程序以及多种神经元记录和分析,都指出了神经元的作用。基底神经节-上丘通路在认知事件中介于视觉和动作之间,例如记忆,目标选择以及扫视选择和评估。

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