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首页> 外文期刊>Current Opinion in Neurobiology >Axon guidance: receptor complexes and signaling mechanisms.
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Axon guidance: receptor complexes and signaling mechanisms.

机译:轴突指导:受体复合物和信号传导机制。

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摘要

The generation of a functional neuronal network requires that axons navigate precisely to their appropriate targets. Molecules that specify guidance decisions have been identified, and the signaling events that occur downstream of guidance receptors are beginning to be understood. New research shows that guidance receptor signaling can be hierarchical - one receptor silencing the other - thereby allowing navigating growth cones to interpret opposing guidance cues. Among the known intracellular signaling molecules shared by all guidance receptor families, Rho GTPases appear to be primary regulators of actin dynamics and growth cone guidance. Novel effector molecules complete the picture and suggest additional signaling mechanisms.
机译:功能神经元网络的产生需要轴突精确地导航至其适当的靶标。已经确定了指定指导决定的分子,并且开始理解在指导受体下游发生的信号传递事件。新的研究表明,引导受体信号可以是分层的-一种受体沉默另一种-从而允许导航生长锥来解释相反的引导信号。在所有导向受体家族共有的已知细胞内信号分子中,Rho GTPases似乎是肌动蛋白动力学和生长锥导向的主要调节剂。新型效应分子使图像更加完整,并暗示了其他信号机制。

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