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Fertility drugs and risk of ovarian cancer: dispelling the myth.

机译：生育药和卵巢癌的风险：消除神话。

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PURPOSE OF REVIEW: Worldwide 50-80 million people suffer from infertility. Assisted reproductive technology has provided a way of overcoming infertility and childlessness.The current article will focus on data linking infertility and its treatment to ovarian cancer. RECENT FINDINGS: Ovarian cancer risks associated with fertility drug treatment are encouraging, but not decisive. In view of the limited ability to evaluate drug effects on borderline tumors, given their rare occurrence, studies involving patient reports of prior drug exposures have noted an elevated risk of borderline tumors associated with fertility drugs. Nevertheless, the risk of invasive ovarian cancer appears to be restricted to those women who remain childless despite the infertility treatment. SUMMARY: As long as doubt persists, it might be advisable to reflect on a few clinical recommendations: identify high-risk infertile patients for ovarian cancer, investigate preexisting cancer before fertility treatment, inform patients regarding potential risks, obtain an informed consent, avoid exposure to long periods of ovulation induction cycles that are given before patients are referred for in-vitro fertilization and embryo transfer for women at greater risk and monitor women who have been treated with these drugs, especially those who failed to conceive, regularly and thoroughly.
机译：审查目的：全世界有50-8000万人患有不育症。辅助生殖技术提供了一种克服不育和无子女的方法。本文将重点关注将不育及其治疗与卵巢癌联系起来的数据。最新发现：与生育药治疗相关的卵巢癌风险令人鼓舞，但不是决定性的。鉴于评估药物对交界性肿瘤的作用的能力有限，鉴于其罕见的发生，涉及患者先前药物暴露报告的研究表明与生育药相关的交界性肿瘤的风险较高。尽管如此，浸润性卵巢癌的风险似乎仅限于尽管进行了不育治疗仍没有孩子的妇女。摘要：只要仍然存在疑问，建议对一些临床建议进行反思：确定卵巢癌的高危不育患者，在进行生育治疗之前调查先前存在的癌症，告知患者潜在风险，获得知情同意，避免接触到较高的风险女性被转介到体外受精和胚胎移植之前给出的长期排卵诱导周期，并监测接受过这些药物治疗的妇女，尤其是那些定期，彻底地未怀孕的妇女。

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