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The role of myomectomy in fertility enhancement.

机译:子宫肌瘤切除术在提高生育能力中的作用。

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摘要

PURPOSE OF REVIEW: To review current available literature on the relationship between fibroids and infertility with particular emphasis on the benefits of myomectomy. Pregnancy complications related to the presence of these lesions and to their removal are also addressed. RECENT FINDINGS: There is a biological plausibility supporting a causal relationship between fibroids and infertility. From a clinical point of view, this association is mostly supported by studies comparing pregnancy rate following IVF in women with and without fibroids. The emerging view is that submucosal, intramural and subserosal fibroids interfere with fertility in decreasing order of importance. There is one randomized controlled trial supporting the benefits of myomectomy in infertile women with fibroids. The beneficial effects of surgery are further supported by insights from clinical series showing that the pregnancy rate following myomectomy is satisfactory and by the strong benefits documented in the few nonrandomized comparative studies. An increased rate of obstetric complications has been reported in women carrying fibroids. Data regarding the course of pregnancy in operated women are scanty. The most significant (although rare) complication is rupture of the uterus during pregnancy or labour. SUMMARY: At present, owing to the lack of adequately designed trials aimed to clearly establish that lesions benefit from surgery, a comprehensive and personalized approach should be adopted. The most important variables to be considered are the age of the woman, the characteristics of the fibroids, the concomitant presence of fibroids-related symptoms and the presence of other causes of infertility.
机译:审查的目的:审查有关肌瘤和不育之间关系的现有文献,特别强调子宫肌瘤切除术的益处。还解决了与这些病变的存在和切除有关的妊娠并发症。最近的发现:有一种生物学上的合理性支持了肌瘤和不孕症之间的因果关系。从临床角度来看,这种关联主要由比较有或没有子宫肌瘤的妇女在IVF后的妊娠率的研究来支持。新兴的观点是,粘膜下,壁内和浆膜下肌瘤以重要性递减的顺序干扰生育。有一项随机对照试验支持肌瘤切除术对不育型肌瘤妇女的益处。来自临床系列的见解进一步证明了手术的有益效果,这些见解表明,子宫肌瘤切除术后的妊娠率令人满意,并且在少数非随机比较研究中记录了强大的益处。据报道,患有肌瘤的妇女的产科并发症发生率增加。有关手术妇女怀孕过程的数据很少。最重要的(尽管很少见)并发症是在怀孕或分娩过程中子宫破裂。摘要:目前,由于缺乏旨在明确确定病变可从手术中获益的充分设计的试验,应采用全面且个性化的方法。要考虑的最重要的变量是妇女的年龄,肌瘤的特征,与肌瘤有关的症状的同时存在以及其他不孕原因的存在。

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