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首页> 外文期刊>Current opinion in obstetrics & gynecology >Poor responder protocols for in-vitro fertilization: options and results.
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Poor responder protocols for in-vitro fertilization: options and results.

机译：体外受精的应答者方案较差：选项和结果。

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PURPOSE OF REVIEW: To present the options and the results in the management of poor responders in in-vitro fertilization. RECENT FINDINGS: There is no controlled ovarian hyperstimulation protocol which is best suited for all poor responders. Low dose gonadotropin-releasing hormone agonist regimes appear to be most advantageous. Prediction of compromised response prior to cycle initiation by a thorough assessment of ovarian reserve as well as a careful review of past responses could allow for a more appropriate selection of a controlled ovarian hyperstimulation protocol for each individual patient. Optimistic data have been presented by the use of high doses of gonadotropins, flare up gonadotropin-releasing hormone agonist protocols (standard or microdose), stop protocols, luteal onset of gonadotropin-releasing hormone agonist, and short protocols. Natural cycle also seems to be an appropriate strategy to be considered. SUMMARY: There is no universal definition for the 'poor responder'. Numerous strategies have been proposed to improve ovarian stimulation in poor responders, but none of them is the ideal for all such patients. More data from good quality controlled trials are needed.
机译：审查目的：介绍在体外受精中不良反应者管理中的选择和结果。最近的发现：没有最适合所有不良反应者的受控卵巢过度刺激方案。低剂量促性腺激素释放激素激动剂方案似乎是最有利的。通过对卵巢储备的全面评估以及对过去反应的仔细审查，可以在周期开始之前预测受损的反应，从而可以为每个患者更合适地选择受控的卵巢过度刺激方案。通过使用高剂量的促性腺激素，使促性腺激素释放激素激动剂方案（标准剂量或微剂量）发作，停止方案，促性腺激素释放激素激动剂的黄体发作和短期方案已显示出乐观的数据。自然周期似乎也是要考虑的适当策略。简介：对于“响应者差”没有统一的定义。已经提出了许多策略来改善反应较差的人的卵巢刺激，但是这些策略都不是所有此类患者的理想选择。需要来自高质量对照试验的更多数据。

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