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Bacterial vaginosis in pregnancy.

机译:妊娠细菌性阴道病。

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摘要

Bacterial vaginosis is associated with adverse pregnancy outcomes across all gestational ages. It is linked to first and second trimester fetal loss, chorioamnionitis, preterm delivery, low-birthweight infants and maternaleonatal infectious morbidity. Infants who survive preterm birth are at an increased risk of subsequent neurodevelopmental delays and handicap, more so if there was underlying choriomnionitis. The exact mechanisms and pathways through which bacterial vaginosis exerts these adverse effects are incompletely understood. Not surprisingly, intervention studies in bacterial vaginosis-positive pregnant women have shown conflicting results, both in women at high and low risk of preterm birth. A much better understanding of the pathobiology of bacterial vaginosis in pregnancy is required to focus the designs of intervention studies on the disturbed cellular and biochemical pathways. Such studies may address the benefits of the treatment of bacterial vaginosis before conception and during early pregnancy, to determine whether treatment in populations of pregnant women may be beneficial.
机译:在所有胎龄中,细菌性阴道病都与不良妊娠结局相关。它与孕早期和孕中期的胎儿流失,绒毛膜羊膜炎,早产,低出生体重的婴儿以及母婴传染病有关。早产后存活的婴儿,其后发生神经发育迟缓和残障的风险增加,如果存在潜在的绒膜膜羊膜炎,则更是如此。细菌性阴道病发挥这些不良作用的确切机制和途径尚不完全清楚。不足为奇的是,对细菌性阴道病阳性孕妇的干预研究已显示出矛盾的结果,无论早产风险高低的妇女均如此。需要对妊娠细菌性阴道病的病理学有一个更好的了解,以将干预研究的设计重点放在受干扰的细胞和生化途径上。此类研究可能会探讨受孕之前和怀孕初期治疗细菌性阴道病的益处,以确定在孕妇人群中治疗是否有益。

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