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首页> 外文期刊>Current Opinion in Neurobiology >Cortico-striatal representation of time in animals and humans.
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Cortico-striatal representation of time in animals and humans.

机译：动物和人类的皮质纹状体时间表示。

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Interval timing in the seconds-to-minutes range is crucial to learning, memory, and decision-making. Recent findings argue for the involvement of cortico-striatal circuits that are optimized by the dopaminergic modulation of oscillatory activity and lateral connectivity at the level of cortico-striatal inputs. Striatal medium spiny neurons are proposed to detect the coincident activity of specific beat patterns of cortical oscillations, thereby permitting the discrimination of supra-second durations based upon the reoccurring patterns of subsecond neural firing. This proposal for the cortico-striatal representation of time is consistent with the observed psychophysical properties of interval timing (e.g. linear time scale and scalar variance) as well as much of the available pharmacological, lesion, patient, electrophysiological, and neuroimaging data from animals and humans (e.g. dopamine-related timing deficits in Huntington's and Parkinson's disease as well as related animal models). The conclusion is that although the striatum serves as a 'core timer', it is part of a distributed timing system involving the coordination of large-scale oscillatory networks.
机译：间隔时间在几秒到几分钟之间，对于学习，记忆和决策至关重要。最近的发现表明皮质-纹状体回路的参与是通过在皮质-纹状体输入水平上的振荡活动和横向连接性的多巴胺能调节而优化的。纹状体中棘神经元被提出来检测皮层振荡特定搏动模式的同时活动，从而允许基于亚秒级神经激发的重复模式来区分超秒持续时间。该提议的皮质-纹状体时间表示与观察到的间隔时间的心理生理特性（例如线性时间标度和标量方差）以及来自动物和动物的许多可用药理，病变，患者，电生理和神经影像学数据一致。人类（例如，亨廷顿氏病和帕金森氏病以及相关动物模型中与多巴胺相关的时间缺陷）。结论是，尽管纹状体充当了“核心计时器”，但它是涉及大规模振荡网络协调的分布式计时系统的一部分。

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