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首页> 外文期刊>Biochimica et biophysica acta. Molecular basis of disease: BBA >Trypanosome alternative oxidase as a target of chemotherapy
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Trypanosome alternative oxidase as a target of chemotherapy

机译：锥虫替代氧化酶作为化疗靶标

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摘要

Parasites have developed a variety of physiological functions necessary for their survival within the specialized environment of the host. Using metabolic systems that are very different from those of the host, they can adapt to low oxygen tension present within the host animals. Most parasites do not use the oxygen available within the host to generate ATP, but rather employ systems anaerobic metabolic pathways. The enzymes in these parasite-specific pathways are potential targets for chemotherapy. Cyanide-insensitive trypanosome alternative oxidase (TAO) is the terminal oxidase of the respiratory chain of long slender bloodstream forms of the African trypanosome, which causes sleeping sickness in human and nagana in cattle. TAO has been targeted for the development of anti-trypanosomal drugs because it does not exist in the host. Recently, we found the most potent inhibitor of TAO to date, ascofuranone, a compound isolated from the phytopathogenic fungus, Ascochyta visiae.
机译：寄生虫已发展出多种生理功能，这些条件对于它们在宿主的特殊环境中生存至关重要。使用与宿主的代谢系统非常不同的代谢系统，它们可以适应宿主动物体内存在的低氧压。大多数寄生虫不使用宿主体内可用的氧气来生成ATP，而是采用系统厌氧代谢途径。这些寄生虫特异性途径中的酶是化学疗法的潜在靶标。对氰化物不敏感的锥虫替代氧化酶（TAO）是非洲锥虫细长血流形式的呼吸链的末端氧化酶，可导致人和牛的长颈鹿昏睡病。由于宿主中不存在TAO，因此已将其作为抗锥虫药物开发的目标。最近，我们发现了迄今为止最有效的TAO抑制剂Ascofuranone，这是一种从植物病原真菌Viscoe中分离出的化合物。

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