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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Hair growth-promoting activities of chitosan and surface-deacetylated chitin nanofibers
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Hair growth-promoting activities of chitosan and surface-deacetylated chitin nanofibers

机译：脱毛茄籽和表面脱乙酰基塔蛋白纳米纤维的头发生长促进活性

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摘要

In this study, the effects of chitosan and surface-deacetylated chitin nanofibrils (SDACNFs) on hair growth were evaluated. In human follicle dermal papilla cells in vitro, chitosan and SDACNFs were shown to increase cell growth on day 3 after the initiation of treatment, together with an increase in the production of fibroblast growth factor-7 (FGF-7) by these cells on day 3. Furthermore, in an in vivo study in mice, chitosan and SDACNF application promoted hair growth. The number of anagen follicles significantly increased compared with that in the control group, whereas the number of telogen follicles significantly decreased in the chitosan and SDACNF groups. In the chitosan and SDACNFs groups, moreover, the expression levels of FGF-7 and Sonic hedgehog were significantly upregulated in hair follicles. Overall, our results demonstrated that chitosan and SDACNFs promoted hair growth and therefore may have applications as novel therapeutic agents for the treatment of hair loss in patients. (C) 2018 Elsevier B.V. All rights reserved.
机译：在这项研究中，评估了壳聚糖和表面脱乙酰丁香蛋白纳米纤维（SDACNF）对毛发生育的影响。在体外的人卵泡皮骨乳头细胞中，显示壳聚糖和SdacNFS在第3天在治疗后第3天提高细胞生长，并在当前这些细胞增加成纤维细胞生长因子-7（FGF-7）的产生增加此外，在小鼠的体内研究中，壳聚糖和SDACNF应用促进了头发生长。与对照组相比，Anagen卵泡的数量显着增加，而在壳聚糖和SDACNF组中遥控卵泡的数量显着降低。此外，在壳聚糖和SDACNFS组中，FGF-7和Sonic Hedgehog的表达水平在毛囊中显着上调。总体而言，我们的结果表明，壳聚糖和SDACNFS促进了毛发生长，因此可能具有作为新型治疗剂的应用，用于治疗患者脱发。 （c）2018年elestvier b.v.保留所有权利。

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