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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Colonic delivery of pelargonidin-3-O-glucoside using pectin-chitosan-nanoliposome: Transport mechanism and bioactivity retention
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Colonic delivery of pelargonidin-3-O-glucoside using pectin-chitosan-nanoliposome: Transport mechanism and bioactivity retention

机译：使用果胶 - 壳聚糖 - 纳米脂质体的脑蛋白-3-O-葡糖苷的结肠递送：运输机制和生物活性保留

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摘要

Colon-targeted delivery is an active area of research as it can improve drug stability, bioactivity, and lessen the systematic toxicity. In this study, the colon-specific delivery of pelargonidin-3-O-glucoside(P3G) was investigated using pectin (P)/chitosan (CH)-functionalized nanoliposome (NL). The food simulant stability, transport mechanism, and bioactivity retention potential of carrier systems were studied. Results showed that polymer coated nanoliposomes (P-CH-NL and CH-NL) improved the thermal and food simulant stability as well as enhanced the P3G retention during the in vitro digestion. The maximum P3G retention after enzymatic and non enzymatic digestion was observed by P-CH-NL and the values were 47.5% and 57.5%, respectively. However, all nanoliposomal carriers followed Fickian diffusion mechanism both in in vitro food simulants and in vitro digestion models. Digested functionalized nanoliposomes revealed higher antioxidant properties after gastric digestion. Following by simulated intestinal fluid digestion, ABTS antioxidant activity of P-CH-P3G-NL was 12.52% and 6.31% higher than that of P3G-NL and CH-P3G-NL, respectively, while DPPH scavenging capacity of P-CH-P3GNL was 5.57% and 1.86% greater than that of P3G-NL and CH-P3G-NL, respectively. Therefore, the developed functionalized nanoliposome can be useful for colon-targeted delivery and applicable in functional foods and/or beverages. (C) 2020 Elsevier B.V. All rights reserved.
机译：结肠靶向递送是一种活跃的研究领域，因为它可以提高药物稳定性，生物活性，并减少系统毒性。在该研究中，使用果胶（P）/壳聚糖（CH） - 官能化的纳米脂体（NL）研究了Pelargonidin-3-O-葡糖苷（P3G）的结肠特异性递送。研究了载体系统的食品模拟稳定性，运输机理和生物活性保留潜力。结果表明，聚合物涂覆的纳米脂质体（P-CH-N1和CH-N1）改善了热和食品模拟稳定性，并提高了体外消化期间的P3G保留。通过P-CH-N1观察酶促和非酶消化后的最大P3G保留，分别为47.5％和57.5％。然而，所有纳米体载体遵循体外食品模拟剂和体外消化模型中的Fickian扩散机制。消化的官能化纳米脂质瘤显示胃消化后较高的抗氧化性能。通过模拟的肠道流体消化，P-CH-P3G-N1的ABTS抗氧化活性分别比P3G-N1和CH-P3G-NL高12.52％和6.31％，而P-CH-P3GNL的DPPH清除能力分别比P3G-NL和CH-P3G-NL大的5.57％和1.86％。因此，开发的官能化的纳米脂体可用于结肠靶向递送并且适用于功能性食品和/或饮料。 （c）2020 Elsevier B.v.保留所有权利。

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