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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Laccase-mediated construction of flexible double-network hydrogels based on silk fibroin and tyramine-modified hyaluronic acid
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Laccase-mediated construction of flexible double-network hydrogels based on silk fibroin and tyramine-modified hyaluronic acid

机译：基于丝素蛋白和酪胺改性透明质酸的碱晶晶介导柔性双网络水凝胶构建

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摘要

Silk fibroin (SF) is a promising biomaterial with attractive properties, however, the practical applications of pure regenerated SF materials were severely restricted by their poor water retention and low elasticity. In this study, a tyramine-modified hyaluronic acid (mHA) was introduced to SF chains, followed by constructing double-network hydrogels via lactase-mediated crosslinking of Si and mHA. Mechanism of the enzymatic coupling reaction between SF and mHA was investigated using the model compounds. The morphology, mechanical properly, and swelling behavior of SF-g-mHA hydrogel were evaluated. The results reveal that combination use of SF and mHA endowed the obtained hydrogels with high structural stability, improved mechanical properties and drug release behavior, which overcame the intrinsically poor formability of the pure fibroin hydrogels. This work provides a novel method to construct a double-network hydrogel with high flexibility and toughness, and expands the application range of the SF-based materials in biomedical fields. (C) 2020 Elsevier B.V. All rights reserved.
机译：丝素蛋白（SF）是一种具有有吸引力的生物材料，但是，纯再生的SF材料的实际应用因其差的水潴留和低弹性而受到严重限制。在该研究中，将酪胺改性的透明质酸（MHA）引入SF链，然后通过乳糖酶介导的Si和MHA交联构建双网络水凝胶。使用模型化合物研究了SF和MHA之间的酶促偶联反应的机制。评估了SF-G-MHA水凝胶的形态，机械正确和溶胀行为。结果表明，SF和MHA的组合使用赋予所得水凝胶具有高结构稳定性，改善机械性能和药物释放行为，其克服纯纤维素水凝胶的内在差的成形性。这项工作提供了一种新的方法来构建具有高柔韧性和韧性的双网络水凝胶，并扩大生物医学领域的SF基材料的应用范围。 （c）2020 Elsevier B.v.保留所有权利。

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