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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >A nonadherent chitosan-polyvinyl alcohol absorbent wound dressing prepared via controlled freeze-dry technology
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A nonadherent chitosan-polyvinyl alcohol absorbent wound dressing prepared via controlled freeze-dry technology

机译：通过受控的冷冻干燥技术制备的非抗壳聚糖 - 聚乙烯醇吸收性伤口敷料

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In modern-day 21st century, the demand has increased for absorbent dressings that are nonadherent and maintain structural integrity without shedding lint in the wound site. This study looks at the development of a blend of polysaccharide chitosan and polyvinyl alcohol (PVA) and its fabrication using a novel controlled freeze-drying process, thus giving it channeled pores. The dressing was assessed for in vitro physical properties such as fluid handling, mechanical integrity, bioadhesion, and blood clotting. Additionally, cytocompatibility and hemocompatibility tests were conducted. An in vitro wound-healing assay was performed to determine the healing response. Furthermore, toxicological safety evaluation tests such as acute systemic toxicity, skin irritation, and sensitization were conducted. The results revealed that the developed dressing was biocompatible with a good absorbency rate of 0.63 +/- 0.13 g/cm(2), enhanced mechanical integrity, and low bioadhesive strength with good healing characteristics and nontoxic nature, which indicated that it was an ideal nonadherent absorbent wound dressing. (c) 2020 Elsevier B.V. All rights reserved.
机译：在现代21世纪中，对吸收剂敷料的需求增加了不正常的，并保持结构完整性而不会在伤口部位脱落的结构完整性。本研究介绍了使用新型控制的冷冻干燥过程的多糖壳聚糖和聚乙烯醇（PVA）的混合物的发展，从而使其引入孔隙。敷料被评估为体外物理性质，如流体处理，机械完整性，生物粘附和血液凝固。另外，进行了细胞偶联和血液化测试。进行体外伤口愈合测定以确定愈合反应。此外，进行毒理学安全评估试验，如急性全身毒性，皮肤刺激和敏化。结果表明，发育的敷料是生物相容的，良好的吸收率为0.63 +/- 0.13g / cm（2），增强机械完整性，低生物粘性强度，具有良好的愈合特性和无毒性质，表明它是一种理想的非闭孔吸收伤口敷料。 （c）2020 Elsevier B.v.保留所有权利。

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