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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Incorporation of Zataria multiflora essential oil into chitosan biopolymer nanoparticles: A nanoemulsion based delivery system to improve the in-vitro efficacy, stability and anticancer activity of ZEO against breast cancer cells
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Incorporation of Zataria multiflora essential oil into chitosan biopolymer nanoparticles: A nanoemulsion based delivery system to improve the in-vitro efficacy, stability and anticancer activity of ZEO against breast cancer cells

机译：将Zataria multiflora精油掺入壳聚糖生物聚合物纳米粒子中：基于纳米乳剂的递送系统，以改善Zeo对乳腺癌细胞的体外功效，稳定性和抗癌活性

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摘要

In the search of new alternative anticancer agents, essential oils (Eos) play a critical role, exerting selective anticancer properties and limiting the toxicity of conventional therapies. However, these compounds still face some challenges. Nanoemulsification (NE) protects labile and sensitive EO ingredients until they are released in the system. Herein, Zataria Multiflora Essential Oil (ZEO) loaded into chitosan (CS) nanoparticles was prepared in aqueous solution by mild emulsification into nanometric particles. FTIR spectroscopy exhibited no covalent interaction between active groups of ZEO and functional groups of CS. The outcomes revealed that CS/ZEONE increasingly improves the proliferation inhibition rate of Breast cancer cells as confirmed by MTT, morphological changes, DNA fragmentation and FACS analyses. Our findings suggested that CS/ZEONE exposure induces apoptosis, generates ROS, and triggers mitochondrial membrane permeabilization as well as DNA damage without harming normal cells. To find out the mechanism more precisely, the interaction of CS/ZEONE with gDNA was elucidated and Intercalative binding with strong stabilization of the DNA helix has been proposed. In conclusion, our data suggested that CS/ZEONE can be further explored as a promising antiproliferative and therapeutic candidate against breast cancer. (C) 2019 Published by Elsevier B.V.
机译：在寻找新的替代抗癌剂，精油（EOS）起到关键作用，施加选择性抗癌性质并限制常规疗法的毒性。然而，这些化合物仍面临一些挑战。纳米乳化（NE）保护不稳定的EO成分，直到它们在系统中释放。在此，通过轻度乳化将负载到壳聚糖（Cs）纳米颗粒中的Zataria multiflora精油（Zeo）在水溶液中制备纳米粒子。 FTIR光谱表现出在Zeo和Cs的官能团之间没有共价相互作用。结果表明，Cs / Zeone越来越多地提高MTT，形态学变化，DNA碎片和FACS分析所证实的乳腺癌细胞的增殖抑制率。我们的研究结果表明，Cs / Zeone暴露诱导细胞凋亡，产生ROS，并触发线粒体膜透射化以及DNA损伤而不妨碍正常细胞。为了更确切地说，阐明了Cs / eone与GDNA的相互作用，提出了与DNA螺旋的强稳定性的相互平移结合。总之，我们的数据表明Cs / Zeone可以进一步探索作为乳腺癌的有前途的抗增殖和治疗候选者。 （c）2019年由elestvier b.v发布。

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