• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Heparan sulfate loaded polycaprolactone-hydroxyapatite scaffolds with 3D printing for bone defect repair
【24h】

Heparan sulfate loaded polycaprolactone-hydroxyapatite scaffolds with 3D printing for bone defect repair

机译：硫酸乙酰肝素负载聚己内酯 - 羟基磷灰石支架，用于骨缺损修复3D印刷

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

With the increasing applications of 3D printing technology in biomedical field, the composition or additives of the related materials has become critical for the next development. In the current study, we have prepared 3D printed polycaprolactone-hydroxyapatite (PCL-HA) porous scaffolds with loaded heparan sulfate (HS), in order to reveal the reparative effect of different concentrations of HS on the healing of bone defects. As a result, the scaffold itself showed sound compression resistance, air porosity and good biocompatibility. From both in vitro and in vivo experiments, the scaffold with low concentration of HS led to positive effects in promoting osteoblast maturation and accelerating bone defect repair. Moreover, scaffold with high concentration of HS showed notable inhibitive effort on the proliferation of osteoblasts, yet it still brought about positive effects in repairing bone defects in organisms. Thus, with good structural properties and biocompatibility, 3D printed PCL-HA-HS composite scaffold can facilitate and accelerate the repairing of biological bone defects, demonstrating as an effective biomaterial for bone defect repair. (C) 2020 Elsevier B.V. All rights reserved.
机译：随着3D打印技术在生物医学领域的应用，相关材料的组成或添加剂对下一步发展至关重要。在目前的研究中，我们制备了3D印刷的聚己内酯 - 羟基磷灰石（PCL-HA）多孔支架与负载的硫酸乙酰肝素（HS），以揭示不同浓度HS对骨缺损愈合的重复效应。结果，支架本身显示出声压缩，空气孔隙率和良好的生物相容性。从体外和体内实验中，具有低浓度HS的支架导致促进成骨细胞成熟和加速骨缺损修复的积极作用。此外，具有高浓度HS的支架对成骨细胞的增殖显示出显着的抑制性努力，但它仍然在修复生物体中的骨缺损方面带来了积极作用。因此，具有良好的结构性和生物相容性，3D印刷PCL-HA-HS复合支架可以促进并加速生物骨缺损的修复，作为骨缺损修复的有效生物材料。 （c）2020 Elsevier B.v.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号