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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Codonopsis lanceolata polysaccharide CLPS alleviates high fat/high sucrose diet-induced insulin resistance via anti-oxidative stress
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Codonopsis lanceolata polysaccharide CLPS alleviates high fat/high sucrose diet-induced insulin resistance via anti-oxidative stress

机译：Codonopsis Lanceolata多糖CLP通过抗氧化应激缓解高脂肪/高蔗糖饮食诱导的胰岛素抗性

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摘要

Polysaccharide has been considered as an important bioactive compound in Codonopsis lanceolata. High fat/high sucrose (HFHS) diet-induced insulin resistance is implicated in multiple metabolic diseases, such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD), these metabolic diseases has become epidemic health issue worldwide. In this study, the effect of C. lanceolata polysaccharide (CLPS) on improving insulin sensitivity in chronic HFHS diet-fed mice was investigated. Our data indicates that CIPS significantly reduced fasting blood glucose (FBG), fasting serum insulin (FINS) and insulin resistance index, in parallel with improved glucose and insulin tolerance impaired by HFHS diet. Impaired phosphorylation of PKB/Akt and hyperphosphorylation of IRS-I at Ser307 were observed in the mice fed with HFHS diet, and those defects were also rescued by CLPS administration. In addition, CLPS caused a significant decrease in the level of malondialdehyde (MDA), and an increase in reduced glutathione (GSH)/oxidised glutathione (GSSG) ratio; concurrent with enhanced expression of antioxidant enzymes including superoxide dismutase (SOD) and catalase (CAT), and activated Nrf2 signaling. In summary, these findings suggest that CLPS ameliorates HFHS diet-induced insulin resistance through activating anti-oxidative signaling pathway, providing new insights into the protective effects of C. lanceolata polysaccharide in metabolic disease.
机译：多糖被认为是Codonopsis典范的重要生物活性化合物。高脂肪/高蔗糖（HFHS）饮食诱导的胰岛素抗性涉及多种代谢疾病，例如2型糖尿病（T2DM）和非酒精性脂肪肝病（NAFLD），这些代谢疾病已成为全球流行病学问题。在本研究中，研究了C.典范多糖（CLPS）对提高慢性HFHS饮食喂食小鼠胰岛素敏感性的影响。我们的数据表明，CIPS显着降低了空腹血糖（FBG），禁食血清胰岛素（FIN）和胰岛素抵抗指数，与HFHS饮食损害的改善葡萄糖和胰岛素耐受性平行。在用HFHS饮食喂养的小鼠中观察到SER307的PKB / AKT的磷酸化和IRS-1的过度磷酸化，并通过CLPS施用来抵押这些缺陷。此外，CLPS在丙二醛（MDA）水平上引起显着降低，以及降低的谷胱甘肽（GSH）/氧化谷胱甘肽（GSSG）比例的增加;同时，具有增强的抗氧化酶表达，包括超氧化物歧化酶（SOD）和过氧化氢酶（猫）和活化的NRF2信号传导。总之，这些研究结果表明，CLP通过激活抗氧化信号通路来改善HFHS饮食诱导的胰岛素抵抗力，从而为代谢疾病中C.典可多糖的保护作用提供了新的见解。

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