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Gum tragacanth-polyvinyl alcohol aerogel for oral delivery of silymarin

机译:用于口服唾液递送的口香糖Tragacanth-聚乙烯醇气凝胶

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This study reports for the first time the fabrication of highly porous aerogels of mixed gum tragacanth-polyvinyl alcohol (GT-PVA) for loading and oral delivery of silymarin (SM). Various analytical techniques were used to investigate changes in the physical, textural, mechanical and microstructural properties of aerogels as affected by blending ratio and vacuum impregnation (VI) of SM. Results showed that the mixing ratio of 1:1 led to aerogels of larger surface area (102920 m(2).g(-1)) and superior physicochemical properties. However, at mixing ratio of 3:1 (GT:PVA) higher loading capacity (4557% +/- 23%) was obtained. SM loading, on the other hand, had an adverse effect on the porosity, microstructure and physical attributes of aerogels transforming them from meso-porous to macro-porous structures. The release rate of SM in simulated gastrointestinal media was found to follow Korsmeyere-Peppas model. (C) 2020 Elsevier B.V. All rights reserved.
机译:本研究报告了第一次制备用于加载和口服递送甲硅烷林(SM)的混合胶曲囊 - 聚乙烯醇(GT-PVA)的高多多孔气凝胶。 使用各种分析技术研究通过SM的混合比和真空浸渍(VI)的影响的气凝胶物理,纹理,机械和微观结构性能的变化。 结果表明,搅拌比为1:1导致较大的表面积的气凝胶(102920 m(2).g(-1))和优异的物理化学性质。 但是,在混合比为3:1(GT:PVA)的加载能力(4557%+/- 23%)。 另一方面,SM载荷对气凝胶的孔隙率,微观结构和物理属性与宏观多孔结构转变为宏观多孔结构的孔隙率,微观结构和物理属性。 发现模拟胃肠介质中SM的释放速率跟随Korsmeyere-Peppas模型。 (c)2020 Elsevier B.v.保留所有权利。

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