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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Universal surface modification using dopamine-hyaluronic acid conjugates for anti-biofouling
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Universal surface modification using dopamine-hyaluronic acid conjugates for anti-biofouling

机译：使用多巴胺 - 透明质酸缀合物进行抗生物纺花的通用表面改性

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摘要

Various materials are used to make implantable devices such as pumps, catheters, and stimulators. However, such implants inevitably undergo biofouling, which is associated with non-specific proteins and cell adhesion on the material surfaces. Severe biofouling often leads to adverse tissue reactions, such as foreign body responses, and thick scar tissue formation around the implantation, which in turn hampers the function and performance of the implants. Herein, a simple and effective surface modification method using dopamine-hyaluronic acid conjugate (DA-HA) is demonstrated to implement anti-biofouling in various biomaterials. DA-HA was synthesized and utilized as a coating material and five commonly used implantable substrates (i.e., polyimide (PI), gold (Au), poly (methyl methacrylate) (PMMA), polytetrafluoroethylene (PTFE), and polyurethane (PU)) were tested for modification with DA-HA. Highly hydrophilic HA chains were immobilized on the substrate surfaces through self-polymerization of DA-HA at an alkaline pH. The DA-HA-modified substrates displayed significant resistance to both non-specific protein adsorption and cell adhesion on the surfaces. In addition, a reduction in scar tissue formation was observed in the DA-HA-coated substrates compared to the unmodified bare substrates after a 4-week subcutaneous implantation. This universal surface coating can be further implemented in various biomedical applications in which severe biofouling is highly undesirable. (C) 2019 Elsevier B.V. All rights reserved.
机译：各种材料用于制造植入装置，例如泵，导管和刺激器。然而，这样的植入物不可避免地经历生物污染，其与非特异性蛋白质和材料表面上的细胞粘附相关联。严重的生物污染往往导致不良组织反应，例如异物反应，围绕植入周围的厚瘢痕组织形成，这反过来妨碍了植入物的功能和性能。这里，对使用多巴胺 - 透明质酸缀合物（DA-HA）的简单且有效的表面改性方法进行说明以在各种生物材料中实施抗生物污垢。 Da-Ha被合成并用作涂料和五种常用的可植入基材（即聚酰亚胺（Pi），金（Au），聚（甲基丙烯酸甲酯）（PMMA），聚四氟乙烯（PTFE）和聚氨酯（PU））用DA-HA测试进行修饰。通过在碱性pH下通过DA-HA的自聚合将高亲水HA链固定在基板表面上。 DA-HA改性的基板显示出对表面上的非特异性蛋白质吸附和细胞粘附的显着性。此外，与在4周皮下植入后的未改性的裸基底相比，在DA-HA涂覆的基材中观察到瘢痕组织形成的减少。这种通用表面涂层可以在各种生物医学应用中进一步实施，其中严重的生物污染是高度不希望的。 （c）2019 Elsevier B.v.保留所有权利。

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