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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Inhibitory activity of biofunctionalized silver-capped N-methylated water-soluble chitosan thiomer for microbial and biofilm infections
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Inhibitory activity of biofunctionalized silver-capped N-methylated water-soluble chitosan thiomer for microbial and biofilm infections

机译：用于微生物和生物膜感染的生物官能化银封端的N-甲基化水溶性壳聚糖硫氨酰胺的抑制活性

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One of the most important self-defense strategies employed by bacteria to resist the action of antibiotics is a biofilm formation upon the infected surface. Thus, there is an urgent need to explore novel candidates that have potent antibacterial and anti-biofilm effects to tackle this challenge. In this endeavor, we have transformed shrimp shell wastes to N-methylated water-soluble chitosan thiomer (MWSCT) which was used as either a chelating agent or bio-reductant and capping agent for Ag(I) ions in the preparation of a Ag(I)MWSCT complex or silver nanocomposite (Ag(0)MWSCT), for targeting antibacterial and anti-biofilm applications. The antibacterial and anti-biofilm performance of the new methylated chitosan thiomer (MWSCT) and its silver architectures (Ag(I) MWSCT, Ag(0)MWSCT) were assessed in vitro against E. coli and S. aureus. These new materials have significant capacities to synergistically inhibit the proliferation of the targeted bacterial cells and biofilm formation, in a structure- and species-dependent manner. Ag(0)MWSCT emerged as the most potent compound in inhibiting the growth of bacterial strains (MICE. coli/MICS. aureus = 0.05/0.34 mu g/mL, 1.6-/2.5-times lower than that recorded for the clinical drug (ciprofloxacin, Cipro). Also, this nanocomposite showed the highest anti-biofilm effects (only 1.7% E. coli biofilm growth; 11.8% staphylococcal biofilm growth). (C) 2020 Elsevier B.V. All rights reserved.
机译：细菌使用的最重要的自卫策略之一是抵抗抗生素的作用是受感染表面上的生物膜形成。因此，迫切需要探索具有有效的抗菌和抗生物膜效果的新候选者来解决这一挑战。在这种努力中，我们将虾壳废弃物转化为N-甲基化水溶性壳聚糖硫聚酯（MWSCT），其用作螯合剂或生物还原剂和用于Ag的Ag（I）离子的封端剂（ i）MWSCT复合物或银纳米复合物（Ag（0）MWSCT），用于靶向抗菌和抗生物膜应用。在体外评估新的甲基化壳聚糖硫聚酯（MWSCT）及其银架构（Ag（I）MWSCT，AG（0）MWSCT）的抗菌和抗生物膜性能（Ag（I）MWSCT），对抗大肠杆菌和金黄色葡萄球菌。这些新材料具有显着的能力，以协同抑制靶向细菌细胞和生物膜形成的增殖，以结构和物种依赖性方式。 Ag（0）MWSCT作为抑制细菌菌株生长的最有效的化合物（小鼠。COURI / MICS。AUREUS = 0.05 /0.34μg/ ml，1.6- / 2.5倍，比临床药物记录的1.6- / 2.5倍（ CiProfloxacin，Cipro）。此外，该纳米复合材料显示出最高的抗生物膜效应（仅1.7％大肠杆菌生物膜生长; 11.8％葡萄球菌生长）。（c）2020 Elsevier BV保留所有权利。

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