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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Sulfated modification, characterization, and potential bioactivities of polysaccharide from the fruiting bodies of Russula virescens
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Sulfated modification, characterization, and potential bioactivities of polysaccharide from the fruiting bodies of Russula virescens

机译：来自Russurch Virescens的结果体的多糖的硫酸化修饰，表征和潜在的生物活性

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摘要

The water-soluble polysaccharide from fruiting bodies of Russula virescens (RVP) was sulfated using sulfur trioxide.pyridine complex method under different reaction conditions. Five sulfated RVP derivatives (SRVP1-5, SRV1-10, SRVP1-15, SRVP1-20 and SRVP1-25) with different degrees of substitution (DS) ranging from 0.34 to 0.73 were prepared. Several structural features of RVP and SRVPs including chemical structure, monosaccharide composition, molecular weight and chain conformation were investigated. The spectra results indicated that the sulfate groups were successfully introduced on RVP. The molecular weights of SRVP decreased with the increasing DS. Both RVP and SRVPs were mainly composed of mannose, glucose and galactose, with different molar ratios. The triple-helical conformation was broken down into a random coil when the DS exceeded 0.34. In vitro activity test results indicated that the SRVPs showed better antioxidant, anticoagulant, antibacterial and antitumor activities compared with RVP. Among the five sulfated derivatives, SRVP1-25 exhibited the strongest ABTS and hydroxyl radical scavenging activities and anticoagulant activity, while SRVP1-20 showed the best antibacterial activity and anti-tumor activity. These results demonstrated that the SRVPs could be developed as one of potential antioxidant, anticoagulant, antibacterial and anti-tumor agents for industrial and biomedical use. (C) 2019 Elsevier B.V. All rights reserved.
机译：使用硫红外异的硫磺酸乙虫（RVP）的水溶性多糖使用硫硫酸化。在不同的反应条件下吡啶复合方法。制备具有不同程度的取代度（DS）的五种硫酸化的RVP衍生物（SRVP1-5，SRV1-10，SRVP1-15，SRVP1-25），范围为0.34至0.73。研究了RVP和SRVP的几种结构特征，包括化学结构，单糖组合物，分子量和链构象。光谱结果表明，在RVP上成功地引入了硫酸盐基团。随着DS的增加，SRVP的分子量降低。 RVP和SRVPS均主要由甘露糖，葡萄糖和半乳糖组成，具有不同的摩尔比。当DS超过0.34时，将三螺旋构象分解为随机线圈。体外活性测试结果表明，与RVP相比，SRVPS显示出更好的抗氧化剂，抗凝血剂，抗菌和抗肿瘤活性。在五种硫酸化衍生物中，SRVP1-25表现出最强的ABTS和羟基自由基清除活性和抗凝血活性，而SRVP1-20显示出最佳的抗菌活性和抗肿瘤活性。这些结果表明，SRVP可以作为工业和生物医学用途的潜在抗氧化剂，抗凝血剂，抗菌和抗肿瘤剂开发。 （c）2019 Elsevier B.v.保留所有权利。

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