• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Structural elucidation and biological aptitude of modified hydroxyethylcellulose-polydimethyl siloxane based polyurethanes
【24h】

Structural elucidation and biological aptitude of modified hydroxyethylcellulose-polydimethyl siloxane based polyurethanes

机译：改性羟乙基纤维素 - 聚二甲基硅氧烷基聚氨酯的结构阐明和生物能力

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The main aim of this research work was to incorporate modified hydroxyethylcellulose (HEC) into PDMS based polyurethanes. In the first part, modification of hydroxyethylcellulose was carried out by polymerizing lactic add (LA) with HEC using ammonia water to prepare poly( lactic acid) grafted hydroxyethylcellulose (HEC-g-PLA).The maximum degree of grafting (59.5%) was achieved at: 1:9 mole ratio of HEC/LA, 2 h, 80 degrees C (for activation) and 4 h, 90 C (for reaction) with 0.74 degree of substitution. In the second part, hydroxyl terminated polybutadiene (HTPB) was reacted with isophorone diisocyanate to produce NCO-terminated polyurethane prepolymer which in turn extended by chain extender to synthesize polydimethyl siloxane hydroxyl terminated (PDMS) based polyurethanes. Effect of incorporation of HEC-g-PLA as a chain extender was studied by varying its mole ratio in PDMS based PUs. Characterization of HEC-g-PIA and all PDMS, HEC-g-PLA based polyurethane samples was carried out by using Fourier Transform Infrared (MR) and proton solid-state NMR SS NMR). Biological behavior of synthesized samples was also tested by various biological activities and results indicated that incorporation of HEC-g-PLA in to PDMS based polyurethanes leads to improvement in antibacterial activity, antibiofilm inhibition, biocompatibility and non-mutagenicity. Therefore, HEC-g-PLA/PDMS blended polyurethanes are promising biomaterials that have potential for various biomedical applications. (C) 2020 Elsevier B.V. All rights reserved.
机译：该研究工作的主要目的是将改性的羟乙基纤维素（HEC）掺入基于PDMS的聚氨酯中。在第一部分中，通过使用氨水将乳酸加入（La）与HEC聚合，制备聚（乳酸）接枝羟乙基纤维素（HEC-G-PLA）来进行羟基乙基纤维素的改性。最大接枝（59.5％）是达到：1：9摩尔比HEC / LA，2小时，80℃（用于活化）和4小时，90℃（反应），取代度为0.74。在第二部分中，将羟基封端的聚丁二烯（HTPB）与异佛酮二异氰酸酯反应以产生NCO封端的聚氨酯预聚物，其又通过链烷基延伸，以合成基于聚二甲基硅氧烷羟基封端（PDMS）的聚氨酯。通过在基于PDMS的PUS中改变其摩尔比，研究了作为链增量剂作为链延伸剂的效果。通过使用傅里叶变换红外（MR）和质子固态NMR SS NMR，进行HEC-G-PIA和所有PDMS的HEC-G-PLA基聚氨酯样品。通过各种生物活性测试合成样品的生物学行为，并表明将HEC-G-PLA掺入PDMS基的聚氨酯，导致抗菌活性，抗菌活性，抗菌抑制，生物相容性和非突变性。因此，HEC-G-PLA / PDMS混合聚氨酯是有希望的生物材料，其具有各种生物医学应用的潜力。 （c）2020 Elsevier B.v.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号