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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Fucoidan from Ecklonia maxima is a powerful inhibitor of the diabetes-related enzyme, alpha-glucosidase
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Fucoidan from Ecklonia maxima is a powerful inhibitor of the diabetes-related enzyme, alpha-glucosidase

机译：来自Ecklonia Maxima的Fucoinean是糖尿病相关酶，α-葡糖苷酶的强大抑制剂

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摘要

Ecklonia maxima, an endemic South African seaweed, is a potential source of beneficial bioactive compounds. Among these compounds, fucoidan, a sulphated polysaccharide has a wide range of bioactivities including anti-diabetic activity. In this study, fucoidan was extracted from E. maxima by the hot water extraction method and then characterised by colorimetric assays for sugar composition. The extraction from E. maxima yielded 6.89% fucoidan which was found to contain 4.45 +/- 0.25% L-fucose and 6.01 +/- 0.53% sulphate. The water extracted E. maxima fucoidan had a low molecular weight of approximately 10 kDa. Structural studies (FT-IR, NMR and XRD) confirmed the structure and integrity of the fucoidan to be similar to previously studied fucoidans in literature. Finally, the activities of starch digestive enzymes; alpha-amylase and alpha-glucosidase, were investigated in the presence of the E. maxima fucoidan extract. Fucoidan from E. maxima was observed to be a potent mixedtype inhibitor of alpha-glucosidase with an IC50 range of 027-0.31 mg.ml(-1), which was significantly lower than the commercial anti-diabetic standard, acarbose. Our present study demonstrated that fucoidan from E. maxima is a more powerful inhibitor compared to some standard anti-diabetic compounds and thus shows great potential for managing type 2 diabetes. (C) 2020 Elsevier B.V. All rights reserved.
机译：Ecklonia Maxima是一个地方南非海藻，是有益生物活性化合物的潜在来源。在这些化合物中，硫化物，硫化多糖具有广泛的生物活性，包括抗糖尿病活性。在该研究中，通过热水萃取方法从E.Maxima中提取Fucoinean，然后通过用于糖组合物的比色测定来表征。来自E.Maxima的萃取产生6.89％的抗藻糖糖，发现含有4.45 +/- 0.25％L-岩藻糖和6.01 +/- 0.53％硫酸盐。水提取的E. Maxima Fucoidan的分子量为约10kDa。结构研究（FT-IR，NMR和XRD）证实了Fucoinoinan的结构和完整性与先前研究的文献中的岩藻葡萄糖等。最后，淀粉消化酶的活性;在E.Maxima Fucoidan提取物的存在下研究了α-淀粉酶和α-葡糖苷酶。来自E.Maxima的抗果环藻是α-葡糖苷酶的有效的混合型抑制剂，IC50范围为027-0.31 mg.ml（-1），其显着低于商业抗糖尿病标准螨梭菌。我们目前的研究表明，与一些标准的抗糖尿病化合物相比，Maxima的Fucoinean是一种更强大的抑制剂，因此显示出2型糖尿病的巨大潜力。 （c）2020 Elsevier B.v.保留所有权利。

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