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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Chitosan-bacterial cellulose patch of ciprofloxacin for wound dressing: Preparation and characterization studies
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Chitosan-bacterial cellulose patch of ciprofloxacin for wound dressing: Preparation and characterization studies

机译：壳聚糖 - 细菌纤维素蛋白纤维素纤维素杂液用于伤口敷料：制备和表征研究

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摘要

Biopolymeric blends based on bacterial cellulose (BC) films modified with low molecular weight chitosan (Chi) were developed for controlled release of ciprofloxacin (Cip). Biophysical studies revealed a compatible and cooperative network between BC and Chi including deep structural changes in the BC matrix shown by spectroscopic and thermal analyses (SEM, roughness analysis, FTIR, XRD, TGA, mechanical properties and water vapor transmission rate). Incorporation of chitosan to BC matrix generated a thickening scaffold with high permeability to water vapor from 0.7 to 3.2 g mm/m(2) h. Cip loaded onto the BC-Chi film showed a hyperbolic release profile with a 30% decrease in antibiotic release mediated by the presence of Chi. BC-Chi blend films containing Cip tested against Pseudomonas aeruginosa and Staphylococcus aureus showed a synergic effect of chitosan on Cip antimicrobial activity. Besides, in vitro studies revealed the lack of cytotoxicity of BC-Chi-Cip films in human fibroblasts. (C) 2019 Elsevier B.V. All rights reserved.
机译：基于用低分子量壳聚糖（CHI）改性的细菌纤维素（BC）薄膜的生物聚糖共混物用于控制释放环丙沙星（CIP）。生物物理研究揭示了BC和Chi之间的兼容性网络，包括光谱和热分析所示的BC矩阵的深层结构变化（SEM，粗糙度分析，FTIR，XRD，TGA，机械性能和水蒸气传动速率）。将壳聚糖掺入BC基质，产生高渗透性的增稠支架，水蒸气从0.7-3.2g mm / m / m（2）h。 CIP加载到BC-CHI薄膜上显示出双曲线释放曲线，通过CHI存在介导的抗生素释放减少30％。含有CIP的BC-Chi混合物薄膜测试针对假单胞菌铜绿假单胞菌和金黄色葡萄球菌的壳聚糖对CIP抗菌活性的协同作用。此外，体外研究表明，在人成纤维细胞中缺乏BC-Chi-CIP膜的细胞毒性。 （c）2019 Elsevier B.v.保留所有权利。

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