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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Sulfated fucan/fucosylated chondroitin sulfate-dominated polysaccharide fraction from low-edible-value sea cucumber ameliorates type 2 diabetes in rats: New prospects for sea cucumber polysaccharide based-hypoglycemic functional food
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Sulfated fucan/fucosylated chondroitin sulfate-dominated polysaccharide fraction from low-edible-value sea cucumber ameliorates type 2 diabetes in rats: New prospects for sea cucumber polysaccharide based-hypoglycemic functional food

机译：低可食用海参的硫酸盐硫酸硫酸岩石化的软骨素硫酸盐束占多糖级分，大鼠的2型糖尿病：海参多糖的新前景基于低血糖功能性食品

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摘要

Sulfated fucan chondroitin sulfate-dominated polysaccharide fraction from low-edible-value sea cucumber may be a good alternative to high-edible-value sea cucumber-derived polysaccharide for application in hypoglycemic functional foods. To evaluate the potential effect of low-edible-value sea cucumber-derived polysaccharide frac-tion on type 2 diabetes (T2DM), two sulfated fucan/fucosylated chondroitin sulfate-dominated polysaccharide fractions screening from 10 global commercial low-edible-value sea cucumber species were investigated to iden-tify their anti-diabetics efficacies using a high-fat diet and streptozotocin-induced T2DM rat model. Sulfated fucan-dominated polysaccharide fraction from Thelenota ananas and fucosylated chondroitin sulfate -dominated polysaccharide fraction from Cucumaria frondosa ameliorated hyperglycemia, restored hypertriglyc-eridemia and hypercholesterolemia, decreased inflammatory status and oxidative stress, protected against liver injury, as well as improved insulin resistance and promoted accumulation of hepatic glycogen by activating IRS/PI3K/AKT signaling and regulating GSK-3 beta gene expression in T2DM rats. The current findings provide an available strategy for the commercialization of sea cucumber polysaccharide based-hypoglycemic functional food. (C) 2020 Elsevier B.V. All rights reserved.
机译：低可食用海参的硫酸盐硫酸盐硫酸脲硫酸脲占多糖级分的硫酸盐束占多糖级分，可以是高可食用海参衍生多糖的替代，用于在降血糖功能食品中应用。评价低可食用海参的潜在效果衍生的多糖FRAC - T2型糖尿病（T2DM），两种硫酸盐的FUCAN /岩藻糖基化的软骨素硫酸盐统治多糖级分筛选，从10个全球商业低可食用海参筛选研究了物种使用高脂饮食和链脲佐菌素诱导的T2DM大鼠模型来识别抗糖尿病患者的抗糖尿病疗效。来自硫顿炎和岩藻糖基的多糖 - 硫酸硫酸岩化多糖部分的硫酸化糖型多糖部分来自Cucumaria Frondosa改善高血糖血症，恢复高原 - 埃里咪唑和高胆固醇血症，降低炎症状态和氧化应激，保护免受肝损伤，以及改善胰岛素抵抗力和促进通过激活IRS / PI3K / AKT信号传导和调节T2DM大鼠GSK-3β基因表达的肝糖原累积。目前的调查结果为海参多糖的基因血糖功能性食品提供了可用的策略。 （c）2020 Elsevier B.v.保留所有权利。

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