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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Cellulose-based polymeric emulsifier stabilized poly(N-vinylcaprolactam) hydrogel with temperature and pH responsiveness
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Cellulose-based polymeric emulsifier stabilized poly(N-vinylcaprolactam) hydrogel with temperature and pH responsiveness

机译：基于纤维素的聚合物乳化剂稳定聚（N-乙烯基己内酰胺）水凝胶，温度和pH响应性

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摘要

N-vinylcaprolactam (NVCL) is a temperature-responsive monomer, which is widely used for preparing responsive hydrogels. However, poor water solubility of NVCL necessitates the use of emulsifiers for better dispersion. Hydrolyzed epoxy soybean oil -grafted hydroxyethyl cellulose (H-ESO-HEC) polymeric emulsifier has excellent emulsifying properties, and the carboxyl groups afford pH-responsiveness to the hydrogels. A novel temperature- and pH-responsive cellulose-based hydrogel was prepared by combining NVCL and H-ESO-HEC. The hydrogel morphology, thermal stability, and swelling capacity were characterized, and it was also used as a dual-responsive drug preservative carrier. Scanning electron microscopy and thermogravimetric analysis confirmed the porous structure and good thermal stability, respectively, of the hydrogel. The hydrogel displayed a temperature- and pH-dependent swelling behavior and improved swelling capacity. The swelling behavior agreed well with the Korsmeyer-Peppas model and Schott's second-order kinetic model. The dual-responsive hydrogel has significant potential in the drug delivery systems owing to its biocompatibility and temperature and pH sensitivity. (C) 2019 Elsevier B.V. All rights reserved.
机译：N-乙烯基己内酰胺（NVCL）是一种温度响应式单体，其广泛用于制备响应性水凝胶。然而，NVC1的水溶解度差需要使用乳化剂以更好地分散。水解环氧豆油 - 移植的羟乙基纤维素（H-ESO-HEC）聚合物乳化剂具有优异的乳化性能，羧基提供给水凝胶的pH反应性。通过组合NVCL和H-ESO-HEC制备新的温度和pH响应纤维素的水凝胶。特征在于水凝胶形态，热稳定性和溶胀容量，也用作双响应药物防腐剂载体。扫描电子显微镜和热重分析证实了水凝胶的多孔结构和良好的热稳定性。水凝胶显示出温度和pH依赖性溶胀行为，并改善溶胀容量。肿胀行为与Korsmeyer-Peppas模型和Schott的二阶动力学模型很好。由于其生物相容性和温度和pH敏感性，双响应水凝胶具有显着的药物递送系统。 （c）2019 Elsevier B.v.保留所有权利。

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  • 来源
  • 作者

    Yang Xinxin; Li Zhaoshuang; Liu He; Ma Lina; Huang Xujuan; Cai Zhaosheng; Xu Xu; Shang Shibin; Song Zhanqian;

  • 作者单位

    Chinese Acad Forestry Inst Chem Ind Forestry Prod Key Lab Biomass Energy &

    Mat Key Lab Chem Engn Forest Prod CoInnovat Ctr Effic Nanjing 210042 Jiangsu Peoples R China;

    Chinese Acad Forestry Inst Chem Ind Forestry Prod Key Lab Biomass Energy &

    Mat Key Lab Chem Engn Forest Prod CoInnovat Ctr Effic Nanjing 210042 Jiangsu Peoples R China;

    Chinese Acad Forestry Inst Chem Ind Forestry Prod Key Lab Biomass Energy &

    Mat Key Lab Chem Engn Forest Prod CoInnovat Ctr Effic Nanjing 210042 Jiangsu Peoples R China;

    Chinese Acad Sci Changchun Inst Appl Chem State Key Lab Electroanalyt Chem Changchun 130022 Peoples R China;

    Yancheng Inst Technol Sch Chem &

    Chem Yancheng 221051 Jiangsu Peoples R China;

    Yancheng Inst Technol Sch Chem &

    Chem Yancheng 221051 Jiangsu Peoples R China;

    Nanjing Forestry Univ Jiangsu Prov Key Lab Chem &

    Utilizat Agoforest Adv Anal &

    Testing Ctr Coll Chem Engn Nanjing 210037 Jiangsu Peoples R China;

    Chinese Acad Forestry Inst Chem Ind Forestry Prod Key Lab Biomass Energy &

    Mat Key Lab Chem Engn Forest Prod CoInnovat Ctr Effic Nanjing 210042 Jiangsu Peoples R China;

    Chinese Acad Forestry Inst Chem Ind Forestry Prod Key Lab Biomass Energy &

    Mat Key Lab Chem Engn Forest Prod CoInnovat Ctr Effic Nanjing 210042 Jiangsu Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物大分子的结构和功能;
  • 关键词

    Responsiveness; Cellulose-based emulsifier; Drug release;

    机译：响应性;基于纤维素的乳化剂;药物释放;

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