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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Chitosan-based advanced materials for docetaxel and paclitaxel delivery: Recent advances and future directions in cancer theranostics
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Chitosan-based advanced materials for docetaxel and paclitaxel delivery: Recent advances and future directions in cancer theranostics

机译：基于Chitosan的多西紫杉醇和PACLITAXEL交付的先进材料：近期进步和癌症治疗的未来方向

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摘要

Paclitaxel (PTX) and docetaxel (DTX) are key members of taxanes with high anti-tumor activity against various cancer cells. These chemotherapeutic agents suffer from a number of drawbacks and it seems that low solubility in water is the most important one. Although much effort has been made in improving the bioavailability of PTX and DTX, the low bioavailability and minimal accumulation at tumor sites are still the challenges faced in PTX and DTX therapy. As a consequence, bio-based nanoparticles (NPs) have attracted much attention due to unique properties. Among them, chitosan (CS) is of interest due to its great biocompatibility. CS is a positively charged polysaccharide with the capability of interaction with negatively charged biomolecules. Besides, it can be processed into the sheet, micro/nano-particles, scaffold, and is dissolvable in mildly acidic pH similar to the pH of the tumor microenvironment. Keeping in mind the different applications of CS in the preparation of nanocarriers for delivery of PTX and DTX, in the present review, we demonstrate that how CS functionalized-nanocarriers and CS modification can be beneficial in enhancing the bioavailability of PTX and DTX, targeted delivery at tumor site, image-guided delivery and co-delivery with other anti-tumor drugs or genes.
机译：Paclitaxel（PTX）和多西紫杉醇（DTX）是紫杉烷群的关键成员，对各种癌细胞具有高抗肿瘤活性。这些化学治疗剂患有许多缺点，似乎在水中的溶解度低是最重要的。虽然已经在提高PTX和DTX的生物利用度方面进行了大量努力，但肿瘤部位的低生物利用度和最小的积累仍然是PTX和DTX治疗中面临的挑战。因此，由于独特的特性，生物基纳米粒子（NPS）引起了很多关注。其中，壳聚糖（CS）由于其巨大的生物相容性而感兴趣。 CS是带有带负电荷的生物分子的相互作用能力的正电荷多糖。此外，可以将其加工成片材，微/纳米颗粒，支架，并且可溶解在类似于肿瘤微环境的pH的温和酸性pH中。在本综述中，请记住CS在编制PTX和DTX中纳米载体的纳米载体的不同应用，我们证明了CS官能化 - 纳米载体和CS改性如何提高PTX和DTX的生物利用度，有针对性的递送在肿瘤部位，图像引导的递送和与其他抗肿瘤药物或基因共同递送。

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