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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Prediction of arsenic and antimony transporter major intrinsic proteins from the genomes of crop plants
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Prediction of arsenic and antimony transporter major intrinsic proteins from the genomes of crop plants

机译：从作物植物基因组中预测砷和锑转运蛋白主要内在蛋白质

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摘要

Major intrinsic proteins (MIPs), commonly known as aquaporins, transport water and non-polar small solutes. Comparing the 3D models and the primary selectivity-related motifs (two Asn-Pro-Ala (NPA) regions, the aromatic/arginine (ar/R) selectivity filter, and Froger's positions (FPs)) of all plant MIPs that have been experimentally proven to transport arsenic (As) and antimony (Sb), some substrate-specific signature sequences (SSSS) or specificity determining sites (SDPs) have been predicted. These SSSS or SDPs were determined in 543 MIPs found in the genomes of 12 crop plants; the As and Sb transporters were predicted to be distributed in noduline-26 like intrinsic proteins (NIPs), and every plant had one or several As and Sb transporter NIPs. Phylogenetic grouping of the NIP subfamily based on the ar/R selectivity filter and FPs were linked to As and Sb transport. We further determined the group-wise substrate selectivity profiles of the NIPs in the 12 crop plants. In addition to two NPA regions, the ar/R filter, and FPs, certain amino acids especially in the pore line, loop D, and termini contribute to the functional distinctiveness of the NIP groups. Expression analysis of transcripts in different organs indicated that most of the As and Sb transporter NIPs were expressed in roots. (C) 2017 Elsevier B.V. All rights reserved.
机译：主要内在蛋白质（MIPS），通常称为水素，运输水和非极性小溶质。比较3D模型和主要选择性相关的主题（两个ASN-Pro-ALA（NPA）区域，所有植物MIPS的所有植物MIPS都是通过实验的所有植物MIPS的植物/精氨酸（AR / R）选择性过滤器经证明转运砷（AS）和锑（SB），已经预测了一些特异性特异性签名序列（SSS）或特异性确定站点（SDP）。这些SSSS或SDP在12种作物植物的基因组中发现的543 MIPS;预计AS和Sb转运蛋白将分布在结核-26中，如本征蛋白（NIPS），并且每株植物都有一种或多种AS和Sb转运蛋白。基于Ar / R选择性过滤器和FPS的NIP亚家族的系统发育分组与AS和Sb传输连接。我们进一步确定了12种作物植物中的咬合的群体基底选择性谱。除了两个NPA区域，AR / R过滤器和FPS之外，特别是在孔线，环D和Termini中的某些氨基酸有助于辊隙组的功能性独特性。不同器官中转录物的表达分析表明，大多数AS和Sb转运蛋白咬合在根中表达。 （c）2017年Elsevier B.V.保留所有权利。

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