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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Doughnut-shaped bovine serum albumin nanoparticles loaded with doxorubicin for overcoming multidrug-resistant in cancer cells
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Doughnut-shaped bovine serum albumin nanoparticles loaded with doxorubicin for overcoming multidrug-resistant in cancer cells

机译：甜甜圈形状的牛血清白蛋白纳米颗粒，用于克服多柔比星，用于克服癌细胞中的多药物

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Traditional spherical albumin nanoparticles remain as the dominant shape of nano-carriers described in the literature at present, due to their simple desolvation method of synthesis. However, non-spherical shapes also show great promise as cancer drug delivery vectors. In this study, we report a novel synthetic strategy based on dimethyl sulfoxide (DMSO) addition during desolvation step, to produce doughnut shaped bovine serum albumin nanoparticles (DBSA-NPs), while maintaining narrow size distributions and homogeneity. The characteristics such as size, polydispersity and doxorubicin loading of prepared DBSA-NPs in comparison with spherical ones were determined. The biodegradation of DBSA-NPs loaded with doxorubicin (Dox-DBSA-NPs) in the presence of trypsin enzyme was spectrophotometrically monitored directly based on doxorubicin release profile. The release profile was analyzed with different kinetic models and it was best fitted with Higuchi kinetics model. The anticancer effect of Dox-DBSA-NPs against lymphoblastic leukemia (MOLT-4) and multidrug resistant uterine sarcoma (MES-SA/DX-5) cell lines were also investigated and the results were comparable with doxorubicin loaded spherical BSA nanoparticles. These results showed the potential of Dox-DBSA-NPs as a novel and high potential nano-carrier for management of non-resistance and also multidrug resistant cancer cells. (C) 2017 Elsevier B.V. All rights reserved.
机译：由于其简单的合成方法，传统的球形白蛋白纳米液纳米颗粒仍然是本发明的文献中描述的纳米载体的主要形状。然而，非球形形状也表现出巨大的希望作为癌症药物递送载体。在这项研究中，我们在去溶剂步骤中报告了一种基于二甲基亚砜（DMSO）加法的新型合成策略，以产生甜甜圈形状的牛血清白蛋白纳米颗粒（DBSA-NPS），同时保持窄尺寸的分布和均匀性。确定了与球形尺寸相比制备的DBSA-NP的尺寸，多分散性和多柔比星载荷的特性。在胰蛋白酶酶的存在下，在胰蛋白酶酶的存在下，在胰蛋白酶酶的存在下加载的DBSA-NPS的生物降解直接基于多柔比蛋白释放曲线分散体监测。用不同的动力学模型分析释放曲线，最适合HIGUCHI动力学模型。还研究了DOX-DBSA-NP对淋巴细胞白血病（MOLT-4）和多药物抗性子宫肉瘤（MES-SA / DX-5）细胞系的抗癌效果，结果与多柔比蛋白负载球形BSA纳米颗粒相当。这些结果表明，DOX-DBSA-NPS作为一种用于管理非阻性和多药抗性癌细胞的新型和高潜在纳米载体。 （c）2017年Elsevier B.V.保留所有权利。

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