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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Structural features of polysaccharides from edible jambo (Syzygium jumbos) fruits and antitumor activity of extracted pectins
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Structural features of polysaccharides from edible jambo (Syzygium jumbos) fruits and antitumor activity of extracted pectins

机译：从食用果酱（Syzygium jumbos）水果和提取果胶的抗肿瘤活性的多糖的结构特征

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摘要

Jambo is a tropical fruit cultivated in Southeast Asia and tropical regions of America and Africa. After extraction, its polysaccharides were structurally characterized. Water soluble polysaccharides (WSP) were composed of GalA:Ara:Gal:Glc:Rha in 51:22:16:5:6 molar ratio, indicating the presence of pectic polysaccharides. Methylation analysis and NMR spectroscopy indicated the presence of homogalacturonan (HG), type II arabinogalactan and type I rhamnogalacturonan (RG-I). The HG/RG-I ratio was 88%, indicating greater amounts of smooth than hairy pectic regions. Hemicellulosic polysaccharides were extracted from the residue and fractionated by freeze-thaw procedure in two fractions (ASP-S and ASP-I). ASP-S was composed of Glc:Gal:Xyl:Ara:Man:Fuc: UA in a 45:16:20:3:8:5:2 molar ratio. Methylation analysis and C-13 NMR spectroscopy indicated xyloglucan, xylan and mannan. Their relative proportion estimated on sugar linkage was 89%, 6% and 3%, respectively. ASP-I was composed mainly of xylose (99.5%) and its C-13 NMR indicated a linear (1 - 4)-beta-D-xylan. The biological activity of WSP was tested in Ehrlich tumor-bearing mice. After 21 days of oral treatment, the doses of 150 and 250 mg/kg WSP reduced expressively the tumor growth, similarly to the positive control methotrexate, and improved the body weight of tumor-bearing mice. Further studies are necessary to investigate the mechanisms of the WSP antitumor effect. (C) 2018 Elsevier BV. All rights reserved.
机译：Jambo是在东南亚和美国热带地区种植的热带水果。萃取后，其多糖在结构上表征。水溶性多糖（WSP）由ARA：ARA：GAL：GLC：rha为51：22：16：5：6摩尔比，表明存在果糖多糖。甲基化分析和NMR光谱表明HomogalactuRonan（Hg）的存在，II型阿拉伯酰亚胺酰胺和I型rhamnogalactuRonan（RG-I）。 Hg / Rg-i比率为88％，表明比毛茸茸地区更大的光滑。从残余物中萃取半纤维素多糖，并通过两个级分（ASP-S和ASP-I）的冻融方法分馏。 ASP-S由GLC：GAL：XYL：ARA：MAN：FUC：UA在45：16：20：3：8：5：2摩尔比例。甲基化分析和C-13核磁共振光谱指示Xyloglucan，Xylan和Mannan。它们估计在糖连锁上的相对比例分别为89％，6％和3％。 ASP-I主要由木糖（99.5％）组成，其C-13 NMR表示线性（1 - ＆ 4）-beta-d-xylan。 WSP的生物活性在EHRLICH肿瘤的小鼠中测试。在口服治疗21天后，剂量为150和250mg / kg WSP表达肿瘤生长，类似于阳性对照甲氨蝶呤，并改善肿瘤小鼠的体重。进一步的研究是研究WSP抗肿瘤效应的机制。 （c）2018 Elsevier BV。版权所有。

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