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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Gelatin/PVA scaffolds fabricated using a 3D-printing process employed with a low-temperature plate for hard tissue regeneration: Fabrication and characterizations
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Gelatin/PVA scaffolds fabricated using a 3D-printing process employed with a low-temperature plate for hard tissue regeneration: Fabrication and characterizations

机译：使用用于硬组织再生的低温板的3D印刷工艺制造明胶/ PVA支架：制造和表征

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Tissue engineering aims to repair or replace damaged tissues or organs using biomedical scaffolds cultured with cells. The scaffolds composed of biomaterials should guide the cells to mature into functional tissues or organs. An ideal scaffold to regenerate hard tissues should have mechanical stability as well as biocompatibititles. It has been well known that gelatin can provide outstanding biological activities, but its low mechanical stability can be one of obstacles to be used in hard tissue regeneration. To overcome the issue, we used PVA, which can reinforce the low mechanical stability of the gelatin. The gelatin/PVA scaffolds have been fabricated using a low temperature 3D-printing process. By manipulating various weight fractions of PVA/gelatin, we can obtain the optimal mixture ratio in aspect of the physical and biological properties of the scaffolds. As a result, a weight fraction of 5:5 showed appropriate mechanical strength and enhanced cell activities, such as cell proliferation and differentiation. The gelatin/PVA scaffold showed potential for future application as biomedical scaffold in soft and hard tissue regeneration. (C) 2018 Published by Elsevier B.V.
机译：组织工程旨在使用用细胞培养的生物医学支架修复或替换受损的组织或器官。由生物材料组成的支架应引导细胞成熟成功能组织或器官。再生硬组织的理想支架应具有机械稳定性以及生物相容性。众所周知，明胶可以提供突出的生物活性，但其低机械稳定性可以是硬组织再生中使用的障碍物之一。为了克服这个问题，我们使用PVA，这可以增强明胶的低机械稳定性。使用低温3D印刷工艺制造明胶/ PVA支架。通过操纵各种重量分数的PVA /明胶，我们可以在支架的物理和生物学性质方面获得最佳混合比。结果，5：5的重量分数显示了适当的机械强度和增强的细胞活性，例如细胞增殖和分化。明胶/ PVA支架显示出未来应用的潜力，作为生物医学支架在软和硬组织再生中。 （c）2018由elestvier b.v出版。

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