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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Modulating carbohydrate-based hydrogels as viscoelastic lubricant substitute for articular cartilages
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Modulating carbohydrate-based hydrogels as viscoelastic lubricant substitute for articular cartilages

机译：调节碳水化合物的水凝胶作为粘弹性润滑剂替代关节软骨

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Viscosupplementation is a therapeutic approach for osteoarthritis treatment, where the synovial fluid, the natural lubricant of the joints, is replaced by viscoelastic solutions with rheological properties comparable or better than the starting material. This study presents the development of an innovative platform for viscosupplementation, based on the optimization of polysaccharide-based colloidal hydrogel, aiming to reduce on-site enzyme degradation and enhance the possibility of hyaluronic acid substitution with alternative biomaterials. Catanionic vesicles are proposed as physical crosslinker that can guarantee the formation of a 'soft', tunable network, offering a dual-therapeutic approach: on the mechanical relief perspective, as well as on the drug/gene delivery strategy. This research focuses on the fabrication and optimization of colloidal networks, driven by the synergistic interaction among catanionic vesicles and cationic modified cellulose polymers. This study tests the hypothesis that cellulose-like polymers can be arranged into functional matrix, mimicking the mechanical properties of healthy synovial fluids. (C) 2017 Elsevier B.V. All rights reserved.
机译：粘度瓶是骨关节炎治疗的治疗方法，其中，与接头的天然润滑剂，粘弹性溶液的粘弹性溶液取代，其流变性质比原料可比或更好。本研究提出了一种基于多糖基胶体水凝胶的优化的粘液化平台的开发，旨在降低现场酶降解，增强透明质酸取代的替代生物材料的可能性。案例囊泡被提出为物理交联剂，可以保证形成“软”，可调网络，提供双治疗方法：在机械浮雕视角以及药物/基因递送策略上。该研究侧重于胶体网络的制造和优化，其由集成囊泡和阳离子改性纤维素聚合物之间的协同相互作用驱动。该研究测试了纤维素样聚合物可以布置成功能基质的假设，模仿健康滑膜流体的机械性能。 （c）2017年Elsevier B.V.保留所有权利。

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