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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Visible and UV-curable chitosan derivatives for immobilization of biomolecules
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Visible and UV-curable chitosan derivatives for immobilization of biomolecules

机译：用于固定生物分子的可见和紫外线固化的壳聚糖衍生物

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摘要

Chitosan, which has many biocompatible properties, is used widely in medical field like wound healing, drug delivery and so on. Chitosan could be used as a biomaterial to immobilize protein-drug. There are many methods to immobilize protein-drug, but they have some drawbacks such as low efficiency and denaturation of protein. Therefore, photo-immobilization method is suggested to immobilize protein drug. Photo-immobilization method is simple-reaction and also needs no additional crosslinking reagent. There has been some effort to modify chitosan to have an ability of photo-immobilization. Generally, visible and UV light reactive chitosan derivatives were prepared. Various types of photo-curable chitosan derivatives showed possibility for application to medical field. For example, they showed ability for protein-immobilization and some of them showed wound-healing effect, anti-adhesive effect, or property to interact directly with titanium surface. In this study, we introduce many types of photo-curable chitosan derivative and their possibility of medical application. (C) 2017 Elsevier B.V. All rights reserved.
机译：壳聚糖具有许多生物相容性的性质，广泛用于伤口愈合，药物递送等的医学领域。壳聚糖可以用作生物材料以固定蛋白质 - 药物。有许多方法可以固定蛋白质 - 药物，但它们具有一些缺点，例如低效率和蛋白质的变性。因此，建议光固化方法固定蛋白质药物。光固定化方法是简单反应，也需要没有额外的交联试剂。有一些努力修饰壳聚糖以具有照片固定化的能力。通常，制备可见光和UV光反应性壳聚糖衍生物。各种类型的光固化壳聚糖衍生物显示出应用于医学领域的可能性。例如，它们显示出蛋白质固定化的能力，其中一些能够直接用钛表面与伤口愈合效果，抗粘接效果或性能进行相互作用。在这项研究中，我们介绍了许多类型的可光固化壳聚糖衍生物及其医学应用的可能性。 （c）2017年Elsevier B.V.保留所有权利。

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