Proarrhythmic proclivity of left-stellate ganglion stimulation in a canine model of drug-induced long-QT syndrome type 1

ter Bekke Rachel M. A.; Moers Annerie M. E.; de Jong Monique M. J.; Johnson Daniel M.; Schwartz Peter J.; Vanoli Emilio; Volders Paul G. A.

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Proarrhythmic proclivity of left-stellate ganglion stimulation in a canine model of drug-induced long-QT syndrome type 1

机译：左侧星状神经节刺激在药物诱导的LONG-QT综合征1型犬模型中的左旋星状神经节刺激

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Background: Left-stellate ganglion stimulation (LSGS) can modify regional dispersion of ventricular refractoriness, promote triggered activity, and reduce the threshold for ventricular fibrillation (VF). Sympathetic hyperactivity precipitates torsades de pointes (TdP) and VF in susceptible patients with long-QT syndrome type 1 (LQT1). We investigated the electromechanical effects of LSGS in a canine model of drug-induced LQT1, gaining novel arrhythmogenic insights.

机译：背景：左侧星状神经节刺激（LSG）可以改变室性耐火性的区域分散，促进触发活性，并降低心室纤维化（VF）的阈值。交感神经多动沉淀出易受QT综合征1型（LQT1）的易感患者患者的扭转指向（TDP）和VF。我们研究了LSGS在药物诱导的LQT1犬模型中的机电效应，新的心律失常见解。

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来源
《International Journal of Cardiology》 |2019年第2019期|共7页
作者
ter Bekke Rachel M. A.; Moers Annerie M. E.; de Jong Monique M. J.; Johnson Daniel M.; Schwartz Peter J.; Vanoli Emilio; Volders Paul G. A.;
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作者单位

Maastricht Univ Med Ctr Cardiovasc Res Inst Maastricht CARIM Dept Cardiol Maastricht;

Maastricht Univ Med Ctr Cardiovasc Res Inst Maastricht CARIM Dept Cardiol Maastricht;

Maastricht Univ Med Ctr Cardiovasc Res Inst Maastricht CARIM Dept Cardiol Maastricht;

Maastricht Univ Med Ctr Cardiovasc Res Inst Maastricht CARIM Dept Cardiol Maastricht;

IRCCS Ist Auxol Italiano Ctr Cardiac Arrhythmias Genet Origin Milan Italy;

Univ Pavia Dept Mol Med Pavia Italy;

Maastricht Univ Med Ctr Cardiovasc Res Inst Maastricht CARIM Dept Cardiol Maastricht;

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原文格式 PDF
正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
Long-QT syndrome; Ventricular arrhythmia; Autonomic nervous system; Torsades de pointes;

机译：long-qt综合征;室性心律失常;自主神经系统;扭曲de pointes;

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1. Proarrhythmic proclivity of left-stellate ganglion stimulation in a canine model of drug-induced long-QT syndrome type 1 [J] . ter Bekke Rachel M. A., Moers Annerie M. E., de Jong Monique M. J., International Journal of Cardiology . 2019,第期

机译：左侧星状神经节刺激在药物诱导的LONG-QT综合征1型犬模型中的左旋星状神经节刺激
2. Antiarrhythmic vs. pro-arrhythmic effects depending on the intensity of adrenergic stimulation in a canine anthopleurin-A model of type-3 long QT syndrome. [J] . Chinushi M, Izumi D, Iijima K, Europace: European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology . 2008,第2期

机译：抗心律失常与促心律失常的作用取决于在3型长QT综合征犬类花粉蛋白素模型中肾上腺素能刺激的强度。
3. Antiarrhythmic vs. pro-arrhythmic effects depending on the intensity of adrenergic stimulation in a canine anthopleurin-A model of type-3 long QT syndrome [J] . Masaomi Chinushi1* Daisuke Izumi2 Kenichi Iijima2 Shizue Ahara1 Satoru Komura2 Hiroshi Furushima2 Yukio Hosaka2 and Yoshifusa Aizawa2 Europace . 2008,第2期

机译：抗心律失常与前心律失常的作用，取决于犬类花青素-A型3型长QT综合征模型中肾上腺素能刺激的强度
4. Differential responses to beta-adrenergic stimulation in the long-QT syndrome type 1: Characterization and mechanisms [C] . David Adolfo Sampedro-Puente, Jesus Fernandez-Bes, Esther Pueyo Computing in Cardiology Conference . 2017

机译：1型长QT综合征对β-肾上腺素能刺激的差异反应：表征和机制
5. A canine model of Imerslund-Grasbeck syndrome: Genetic mapping, mutation identification and functional analysis. [D] . He, Qianchuan. 2005

机译：艾默斯隆-格拉斯贝克综合征的犬科动物模型：遗传作图，突变鉴定和功能分析。
6. Case ascertainment and estimated incidence of drug-induced long-QT syndrome: study in Southwest France [O] . Mariam Molokhia, Atul Pathak, Maryse Lapeyre-Mestre, 2008

机译：病例确定和药物诱发的长期QT综合征的估计发病率：在法国西南部的研究
7. Proarrhythmic proclivity of left-stellate ganglion stimulation in a canine model of drug-induced long-QT syndrome type 1 [O] . Rachel M.A. ter Bekke, Annerie M.E. Moers, Monique M.J. de Jong, 2019

机译：左侧星状神经节刺激在药物诱导的LONG-QT综合征1型犬模型中的左旋星状神经节刺激

Proarrhythmic proclivity of left-stellate ganglion stimulation in a canine model of drug-induced long-QT syndrome type 1

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