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首页> 外文期刊>International Journal of Pharmaceutics >Development of a mucoadhesive delivery system for control release of doxepin with application in vaginal pain relief associated with gynecological surgery
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Development of a mucoadhesive delivery system for control release of doxepin with application in vaginal pain relief associated with gynecological surgery

机译：用妇科手术治疗妇科疼痛缓解粘膜释放系统的粘膜粘附递送系统

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Graphical abstract Display Omitted Abstract The main purpose of this study was to develop a semisolid mucoadhesive formulation for the non-invasive vaginal administration of doxepin (DOX) for relief of pain derived from the scarring process after surgery. An orafix ? platform loading DOX was tested for adequate stability, rheology and vaginal mucoadhesion capacity. The formulation exhibited appropriate pH and was microbiologically stable. The rheological studies confirmed its pseudoplastic and thixotropic nature with prevalence of the elastic behavior component over the viscous one. Appropriate syringeability and spreadability results were also confirmed. Different experiments showed adequate mucoadhesion capacity even in the presence of simulated vaginal fluid. Finally, DOX release, permeation and retention in vaginal mucosa studies were also accomplished with promising results. DOX release kinetics followed the modified Higuchi model and the permeation studies did not render such high values as to suggest potential systemic absorption which could lead to undesirable systemic side effects. Therefore, we can hypostatize that the proposed formulation may assist to fill in the therapeutic gap regarding pure pain relief at local level in vagina.
机译：图解摘要展示摘要本研究的主要目的是开发半固体粘膜粘附配方，用于脱尾（DOX）的非侵入性阴道施用，以缓解手术后瘢痕过程的疼痛。一个orafix？测试平台装载DOX以获得足够的稳定性，流变学和阴道粘膜容量。制剂表现出适当的pH并进行微生物稳定性。流变研究证实了其假塑性和触变性质，其具有粘性的弹性行为组分的患病率。还确认了适当的压织性和可铺展性结果。即使在模拟的阴道液体存在下，不同的实验也表现出足够的粘膜容量。最后，在阴道粘膜研究中，也完成了Dox释放，渗透和保留，并且在有希望的结果中也完成了。 Dox释放动力学遵循改进的HIGUCHI模型，渗透研究没有呈现这种高值，以表明可能导致不希望的系统性副作用。因此，我们可以高兴地解吸，所提出的配方可以帮助填补阴道局部局部水平纯疼痛缓解的治疗差距。

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