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首页> 外文期刊>International Journal of Pharmaceutics >Lycopene loaded whey protein isolate nanoparticles: An innovative endeavor for enhanced bioavailability of lycopene and anti-cancer activity
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Lycopene loaded whey protein isolate nanoparticles: An innovative endeavor for enhanced bioavailability of lycopene and anti-cancer activity

机译：番茄红素装载乳清蛋白分离纳米粒子：一种创新致力于增强番茄红素和抗癌活动的生物利用度

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The work entails a novel strategy of formulating the lycopene loaded whey protein isolate nanoparticles (LYCWPI-NPs) solely using the rational blend of biomacromolecule without using equipment-intensive techniques. The LYC-WPI-NPs were fabricated as a substantial drug delivery platform, with maximum entrapment, spatial and controlled release manners, exceptional plasma concentration, and perspective for discrepancy delivery of therapeutics. Prepared nano-formulations were measured in ultra-fine size (100-350 nm) with sphere-shaped. The percent lycopene entrapment of prepared LYC-WPI-NPs was estimated in the range to 50 and 65%. In vitro percent cumulative release study demonstrated deaden and extended release i.e. approximately 75% following 16th h. The in vitro percent cell survival (cytotoxicity study) of prepared nanoparticles was evaluated against MCF-7 breast cancer cells by MTT based colorimetric assay. Sub-cellular localization of lycopene when delivered by LYC-WPI-NPs was assessed by HPLC (high performance liquid chromatography). The WPI-NPs enhance the oral bioavailability of lycopene by controlling its release from nano-formulation and facilitating its absorption through lymphatic pathways. Prophylactic anticancer efficacy of LYC-WPI-NPs was evaluated thereafter on experimentally induced breast cancer animal model. Conclusively, it may quite reasonable that lycopene loaded protein nanoparticles are competent to improve the biopharmaceutical attributes of lycopene and demonstrated prophylactic anticancer activity, decrease tumor proliferation and increase the survival rate of treated animals, thus signifying their feasible usefulness in cancer therapeutic and intervention.
机译：该作品需要一种新颖的策略，其单独使用BioMacromolecule的合理共混物在不使用设备 - 密集型技术的情况下使用BioMacromolecule的合理共混物配制番茄红素的乳清蛋白分离纳米颗粒（Lycwpi-NPS）。将Lyc-WPI-NPS作为一种大量药物递送平台制造，具有最大的夹带，空间和控制的释放方式，特殊的血浆浓度，以及用于治疗的差异差异的透视。用球形的超细尺寸（100-350nm）测量制备的纳米制剂。将制备的LYC-WPI-NPS的番茄红素抑制百分比估计为50％和65％。体外累积释放研究证明了减少和延长释放等。16小时后约75％。通过基于MTT的比色测定法评估制备纳米颗粒的体外百分比（细胞毒性研究）对MCF-7乳腺癌细胞评估。通过HPLC（高效液相色谱法）评估番茄红素时番茄红素的亚细胞定位。 WPI-NPS通过从纳米制剂中释放并通过淋巴途径进行促进其吸收来增强番茄红素的口服生物利用度。在实验诱导的乳腺癌动物模型中评价了LYC-WPI-NPS的预防抗癌疗效。结论，番茄红素负载蛋白纳米粒子有能力提高番茄红素的生物制药属性并证明预防性抗癌活性，降低肿瘤增殖并提高治疗动物的存活率，从而引起其在癌症治疗和干预中可行的有用性，降低肿瘤增殖。

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