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首页> 外文期刊>International Journal of Pharmaceutics >Multifunctional magnetic-gold nanoparticles for efficient combined targeted drug delivery and interstitial photothermal therapy
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Multifunctional magnetic-gold nanoparticles for efficient combined targeted drug delivery and interstitial photothermal therapy

机译：多官能磁性金纳米颗粒，用于有效联合靶向药物递送和间质性光热疗法

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Abundant efforts have recently been made to design potent theranostic nanoparticles, which combine diagnostic and therapeutic agents, for the effective treatment of cancer. In this study, we developed multifunctional magnetic gold nanoparticles (MGNPs) that are able to (i) selectively deliver the drug to the tumor site in a controlled-release manner, either passively or by using magnetic targeting; (ii) induce photothermal therapy by producing heat by near-infrared (NIR) laser absorption; and (iii) serve as contrast agents for magnetic resonance imaging (MRI) (imaging-guided therapy). The prepared MGNPs were characterized by different physical techniques. They were then coated and conjugated with polyethylene glycol (PEG) and doxorubicin (DOX) to form MGNP-DOX conjugates. The high efficacy of MGNP-DOX for combined chemo-photothermal therapy was observed both in vitro and in vivo. The effectiveness of MGNP-DOX as theranostic nanoparticles was confirmed by histopathological examination and immunohistochemical studies. Moreover, MGNP-DOX showed good potential as MRI contrast agents for guided chemo-photothermal synergistic therapy.
机译：最近努力设计有效的疗效纳米颗粒，其结合诊断和治疗剂，用于有效治疗癌症。在该研究中，我们开发了能够（i）的多功能磁性金纳米颗粒（MgNP）以被动或通过使用磁靶向以控制释放方式选择性地将药物递送至肿瘤部位; （ii）通过近红外线（NIR）激光吸收通过产生热量来诱导光热疗法; （iii）用作磁共振成像（MRI）的造影剂（显影引导疗法）。制备的MGNP以不同的物理技术为特征。然后将它们与聚乙二醇（PEG）和多柔比星（DOX）涂覆和缀合以形成MGNP-DOX缀合物。在体外和体内观察到MgNP-Dox用于组合的化学光热疗法的高效力。通过组织病理学检查和免疫组织化学证实了MGNP-DOX作为治疗纳米粒子的有效性。此外，MgNP-DOX显示出良好的潜在作为引导的化学光热协同疗法的MRI造影剂。

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