• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Pharmaceutics >Self-assembly properties, aggregation behavior and prospective application for sustained drug delivery of a drug-participating catanionic system.
【24h】

Self-assembly properties, aggregation behavior and prospective application for sustained drug delivery of a drug-participating catanionic system.

机译：用于药物参与的持续药物递送的自组装性质，聚合行为和预期应用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In the present study, the self-assembly properties, aggregation behavior and potential application of mixed samples formed by an active drug (diclofenac sodium, DS) and conventional surfactant (didodecyldimethyl ammonium bromide, DDAB) are investigated with surface tension, transmission electron microscope (TEM), dynamic light scattering (DLS), zeta potential, conductivity, in vitro drug release and hemolytic toxicity measurements. The physicochemical parameters such as critical micelle concentration (CMC), the surface tension at CMC (γCMC), the maximum surface excess concentration (Γ max) and the minimum area per molecule headgroup at the air/water interface (A min) and degree of counterion binding (β) are obtained from the surface tension and electrical conductivity measurements. The results show that diclofenac sodium can decrease the surface tension of water and aggregate in the aqueous solution when its concentration is large enough. The CMC and γCMC of the DS/DDAB mixed systems are found to have values between that of individual DS and DDAB solutions. TEM and DLS results demonstrate the formation of spherical vesicles in a wide range of the molar ratio of the two components. The amount of charge on the vesicles and their stability can be tuned by controlling the amount of drug and surfactant. To evaluate the potential use of the as-prepared DS/DDAB catanionic vesicles in drug delivery systems, the in vitro drug release and hemolytic toxicity are carried out. The results indicate that both the drug release behavior and the hemolytic toxicity are dependent on the composition of the samples, X1 (X1=nDS/n(DS+DDAB), decreasing with the decrease of X1. The results of this work suggested that the drug-participating catanionic vesicles can be used as a safe and an efficient vehicle for sustained drug release.
机译：在本研究中，用表面张力，透射电子显微镜（透射电子显微镜）研究了由活性药物（双氯氟乙烯钠，DS）和常规表面活性剂（DEDODECYLDIMEDIMICE，DDAB）形成的自组装性质，聚集性能和潜在应用。 TEM），动态光散射（DLS），Zeta电位，电导率，体外药物释放和溶血性毒性测量。诸如临界胶束浓度（CMC）的物理化学参数，CMC（γCMC）的表面张力，最大表面过量浓度（γmax）和空气/水界面（分钟）和度数的每分子头组的最小面积抗衡离子绑定（β）是从表面张力和电导率测量获得的。结果表明，当其浓度足够大时，双氯芬酸钠钠可以降低水和聚集在水溶液中的聚集体。发现DS / DDAB混合系统的CMC和γCMC具有单独的DS和DDAB解决方案之间的值。 TEM和DLS结果证明了两种组分的较宽摩尔比中的球形囊泡的形成。通过控制药物和表面活性剂的量，可以调节囊泡上的电荷及其稳定性。为了评估药物递送系统中的AS制备的DS / DDAB菌囊泡的潜在使用，进行体外药物释放和溶血性毒性。结果表明，药物释放行为和溶血性毒性都取决于样品X1（X1 = NDS / N（DS + DDAB）的组成，随着X1的减少而降低。这项工作的结果表明参与药物的囊泡囊泡可用作安全和有效的持续药物释放的载体。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号